Nutritional, Physical, Cognitive, and Combination Interventions and Frailty Reversal among Older Adults: A Randomized Controlled Trial

Ng TP, Feng L, Nyunt MSZ et al. American J Med 2015; 128: 1225 – 1236

• Literatur

• 1 Cameron ID, Fairhall N, Langron C et al. A multifactorial interdisciplinary intervention reduces frailty in older people: randomized trial. BMC Med 2013; 11: 65
• 2 Cesari M, Vellas B, Hsu FC et al. A Physical Activity Intervention to Treat the Frailty Syndrome in Older Persons – Results From the LIFE-P Study. J Gerontol A Biol Sci Med Sci 2015; 70: 216-222
• 3 Clegg A, Young J, Iliffe S et al. Frailty in elderly people. Lancet 2013; 381: 752-762
• 4 De Vries NM, van Ravensberg CD, Hobbelen JS et al. Effects of physical exercise therapy on mobility, physical functioning, physical activity and quality of life in community-dwelling older adults with impaired mobility, physical disability and/or multi-morbidity: a meta-analysis. Ageing Res Rev 2012; 11: 136-149
• 5 Fairhall N, Langron C, Sherrington C et al. Treating frailty – a practical guide. BMC Med 2011; 9: 83
• 6 Fried LP, Tangen CM, Walston J et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001; 56: 56
• 7 Gordon AL, Masud T, Gladman JRF. Now that we have a definition for physical frailty, what shape should frailty medicine take?. Age Ageing 2014; 43: 8-9
• 8 Milne AC, Avenell A, Potter J. Meta-analysis: protein and energy supplementation in older people. Ann Intern Med 2006; 144: 37-48
• 9 Nelson ME, Rejeski WJ, Blair SN et al. Physical activity and public health in older adults: recommendation from the American College of Sports Medicine and the American Heart Association. Circulation 2007; 116: 1094-1105
• 10 Payette H, Boutier V, Coulombe C et al. Benefits of nutritional supplementation in free-living, frail, undernourished elderly people: a prospective randomized community trial. J Am Diet Assoc 2002; 102: 1088-1095
• 11 Rockwood K. Making mobility-related disability better: a complex response to a complex problem. BMC Med 2012; 10: 121
• 12 Shamliyan T, Talley KMC, Ramakrishnan R et al. Association of frailty with survival: a systematic literature review. Ageing Res Rev 2013; 12: 719-736
• 13 Smith-Ray RL, Hughes SL, Prohaska TR et al. Impact of Cognitive Training on Balance and Gait in Older Adults. J Gerontol B Psychol Sci Soc Sci 2015; 70: 357-366
• 14 Smoliner C, Norman K, Scheufele R et al. Effects of food fortification on nutritional and functional status in frail elderly nursing home residents at risk of malnutrition. Nutrition 2008; 24: 1139-1144
• 15 Theou O, Stathokostas L, Roland KP et al. The effectiveness of exercise interventions for the management of frailty: a systematic review. J Aging Res 2011; 2011: 1-19
• 16 Theou O, Cann L, Blodgett J et al. Modifications to the frailty phenotype criteria: Systematic review of the current literature and investigation of 262 frailty phenotypes in the Survey of Health, Ageing, and Retirement in Europe. Ageing Res Rev 2015; 21: 78-94
• 17 Turner G, Clegg A. Best practice guidelines for the management of frailty: a British Geriatrics Society, Age UK and Royal College of General Practitioners report. Age Ageing 2014; 43: 744-747
• 18 Verghese J, Mahoney J, Ambrose AF et al. Effect of cognitive remediation on gait in sedentary seniors. J Gerontol A Biol Sci Med Sci 2010; 65: 1338-1343