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Journal of Pediatric Neurology 2006; 04(03): 183-185
DOI: 10.1055/s-0035-1557328
Case Report
Georg Thieme Verlag KG Stuttgart – New York

Methotrexate: A new treatment in opsoclonus-myoclonus syndrome

Christian Denne
a   Department of Pediatrics, RWTH, University Hospital Aachen, Aachen, Germany
,
Michael Kleines
b   Department of Virology, RWTH, University Hospital Aachen, Aachen, Germany
,
Simone Scheithauer
b   Department of Virology, RWTH, University Hospital Aachen, Aachen, Germany
,
Gerhard Heimann
a   Department of Pediatrics, RWTH, University Hospital Aachen, Aachen, Germany
,
Martin Häusler
a   Department of Pediatrics, RWTH, University Hospital Aachen, Aachen, Germany
› Author Affiliations
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Publication History

11 November 2005

23 March 2006

Publication Date:
29 July 2015 (online)

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Abstract

We report a girl with opsoclonus-myoclonus syndrome related to cerebral rubella infection that relapsed during adrenocorticotropin monotherapy but stabilized with methotrexate add-on treatment. Methotrexate may be a new therapeutic option in opsoclonus-myoclonus syndrome, reducing the need for long-term high-dose adrenocorticotropin treatment and the risk of steroid-related side effects.

Keywords

Opsoclonus - myoclonus - methotrexate - ACTH - rubella