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Drug Res (Stuttg) 2014; 64(02): 98-103
DOI: 10.1055/s-0033-1353173
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Synthesis, Antimicrobial Evaluation and QSAR Studies of Stearic Acid Derivatives

S. Tahlan
1   Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, India
,
P. Kumar
2   Pharmaceutical Sciences, Dayanand University, Rohtak, India
,
B. Narasimhan
3   Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, India
› Author Affiliations
Further Information

Publication History

received 01 July 2013

accepted 25 July 2013

Publication Date:
25 September 2013 (online)

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Abstract

A series of Schiff bases (1–17) and esters (18–28) of stearic acid was synthesized and characterized by physicochemical as well as spectral means. The synthesized compounds were evaluated in vitro for their antimicrobial activity by tube dilution method. The antimicrobial screening results indicated that the compounds having electron releasing groups on benzylidene nucleus were found to be more active against bacterial strains and compounds having electron withdrawing groups on benzylidene nucleus were found to be more active against fungal strains. QSAR studies demonstrated that electronic parameters dipole moment (µ) and total energy (Te) were the most important descriptors in describing the antimicrobial activity of synthesized stearic acid derivatives.

Key words

stearic acid derivatives - antibacterial - antifungal - QSAR
 

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