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Semin Thromb Hemost 2013; 39(05): 559-566
DOI: 10.1055/s-0033-1343894
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Sepsis and Thrombosis

Marcel Levi
1   Department of Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
,
Marcus Schultz
2   Department of Intensive Care, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
,
Tom van der Poll
1   Department of Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
3   Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
4   Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
› Author Affiliations
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Publication History

Publication Date:
27 April 2013 (online)

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Abstract

Activation of coagulation frequently occurs in severe infection and sepsis and may contribute to the development of thrombosis. Coagulation abnormalities in sepsis range from a small decrease in platelet count and subclinical prolongation of global clotting times to fulminant disseminated intravascular coagulation (DIC), characterized by simultaneous widespread microvascular thrombosis and profuse bleeding from various sites. Septic patients with severe forms of DIC may present with manifest thromboembolic disease or clinically less apparent microvascular fibrin deposition, which predominantly presents as multiple organ dysfunction. Thrombophilia is associated with a prohemostatic state and consequently with an increased tendency to develop thrombosis. Hypothetically, patients with thrombophilia may suffer from more severe coagulopathy in case of severe infection or sepsis, which may result in a more serious clinical course and an unfavorable outcome. On the basis of the knowledge of the pathogenesis of thrombosis in severe inflammation and sepsis, strategies aimed at the inhibition of coagulation activation have been developed and have been found favorable in experimental and clinical studies.

Keywords

sepsis - thrombosis - inflammation - thrombophilia - heparin
 

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