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Aktuelle Rheumatologie 2011; 36(6): 361-365
DOI: 10.1055/s-0031-1279697
Übersichtsarbeit

© Georg Thieme Verlag KG Stuttgart · New York

Geschlechtsbezogene Aspekte bei Patienten mit Spondyloarthritis

Gender Aspects in Patients with SpondyloarthritisU. Kiltz1 , J. Braun1
  • 1Rheumazentrum Ruhrgebiet, Herne
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Publikationsverlauf

Publikationsdatum:
20. Juni 2011 (online)

Auch verfügbar auf
    Lizenzen und Reprints

Zusammenfassung

Bei Patienten mit Spondyloarthritiden gibt es geschlechtsbezogene Unterschiede in Krankheitsausprägung und Verlauf. Dies hat mögliche Auswirkungen auf Diagnostik und Therapie der Patienten.

Abstract

There are gender-related aspects concerning the severity and the course of the disease in patients with spondyloarthritis. These differences may have an impact on the diagnosis and therapy for these patients.

Schlüsselwörter

Spondyloarthritis - Ankylosierende Spondylitis - Diagnose - Bildgebung - Therapie

Key words

spondyloarthritis - ankylosing spondylitis - diagnosis - radiography - therapy

Literatur

  • 1 Rudwaleit M, van der Heijde D, Landewé R. et al . The Development of Assessment of SpondyloArthritis international Society (ASAS) Classification Criteria for Axial Spondyloarthritis (Part II): Validation and Final Selection.  Ann Rheum Dis. 2009;  68 777-783
    CrossrefPubMedGoogle Scholar
  • 2 Rudwaleit M van, der Heijde D, Landewè R. et al . The development of Assessment of SpondyloArthritis International Society classification criteria for peripheral spondyloarthritis and spondyloarthritis in general.  Ann Rheum Dis. 2011;  70 25-31
    CrossrefPubMedGoogle Scholar
  • 3 Braun J, Sieper J. Ankylosing spondylitis.  Lancet. 2007;  369 1379-1390
    CrossrefPubMedGoogle Scholar
  • 4 Polley HF, Slocumb CH. Rheumatoid Spondylitis: a study of 1 035 cases.  Ann Arch Intern Med. 1947;  26 240-249
    PubMedGoogle Scholar
  • 5 Kennedy LG, Will R, Calin A. Sex ratio in the spondyloarthropathies and its relationship to phenotypic expression, mode of inheritance and age at onset.  J Rheumatol. 1993;  20 1900-1904
    PubMedGoogle Scholar
  • 6 Deutsches Rheuma-Forschungszentrum Berlin. Ausgewählte Aspekte der Erwachsenen Kerndokumentation . http://dgrh.de/fileadmin/media/Forschung/Versorgungsforschung/ErwachsenenKerndok/standardpraesentation_kerndoku_dgrh_website_07_04_2009.pdf online geprüft am 14.01.2011
    PubMed
  • 7 Calin A, Brophy S, Blake D. Impact of sex on inheritance of ankylosing spondylitis: a cohort study.  Lancet. 1999;  354 1687-1690
    CrossrefPubMedGoogle Scholar
  • 8 Miceli-Richard C, Said-Nahal R, Breban M. Impact of sex on inheritance of ankylosing Spondylitis [letter].  Lancet. 2000;  355 1097-1098
    CrossrefPubMedGoogle Scholar
  • 9 Brophy S, Taylor G, Blake D. et al . The Interrelationship Between Sex, Susceptibility Factors, and Outcome in Ankylosing Spondylitis and Its Associated Disorders Including Inflammatory Bowel Disease, Psoriasis, and Iritis.  J Rheumatol. 2003;  30 2054-2058
    PubMedGoogle Scholar
  • 10 Straub RH, Struharova S, Schölmerich J. et al . No alterations of serum levels of adrenal and gonadal hormones in patients with ankylosing spondylitis.  Clin Exp Rheumatol. 2002;  20 (S 28) S52-S59
    PubMedGoogle Scholar
  • 11 Gooren LJ, Giltay EJ, van Schaardenburg D. et al . Gonadal and adrenal sex steroids in ankylosing Spondylitis.  Rheum Dis Clin North Am. 2000;  26 968-987
    PubMedGoogle Scholar
  • 12 Jiminez-Balderas FJ, Tapia-Serrano R, Madero-Cervera JI. et al . Ovarian function studies in active ankylosing spondylitis in women. Clinical response to estrogen therapy.  J Rheumatol. 1990;  17 497-502
    PubMedGoogle Scholar
  • 13 Averns HL, Oxtoby J, Taylor HG. et al . Smoking and outcome in ankylosing spondylitis.  Scand J Rheumatol. 1996;  25 138-142
    CrossrefPubMedGoogle Scholar
  • 14 Ward MM. Predictors of the Progression of Functional Disability in Patients with Ankylosing Spondylitis.  J Rheumatol. 2002;  29 1420-1425
    PubMedGoogle Scholar
  • 15 Lee W, Reveille JD, Davis Jr JC. et al . Are there gender differences in the severity of ankylosing spondylitis? Results from the PSOAS cohort.  Ann Rheum Dis. 2007;  66 633-638
    CrossrefPubMedGoogle Scholar
  • 16 Feldtkeller E, Khan MA, van der Linden S. et al . Age at disease onset and diagnosis delay in HLA-B27 negative vs.  positive patients with ankylosing spondylitis Rheumatol. 2003;  23 61-66
    PubMedGoogle Scholar
  • 17 Van der Linden SM, Valkenburg HA, de Jongh BM. et al . The risk of developing ankylosing spondylitis in HLA B 27 positive individuals. A comparison of relatives of spondylitis patients with the general population.  Arthritis Rheum. 1984;  27 241-249
    CrossrefPubMedGoogle Scholar
  • 18 Rudwaleit M, Haibel H, Baraliakos X. et al . The Early Disease Stage in Axial Spondyloarthritis.  Arthritis Rheum. 2009;  60 717-727
    CrossrefPubMedGoogle Scholar
  • 19 Sampaio-Barros PD, Conde RA, Donadi EA. et al . Undifferentiated Spondyloarthropathies in Brazilians: Importance of HLA-B27 and the B7-CREG Alleles in Characterization and Disease Progression.  J Rheumatol. 2003;  30 2632-2637
    PubMedGoogle Scholar
  • 20 Rojas-Vargas M, Munoz-Gomaris E, Escudero A. et al . First signs and symptoms of Spondyloarthritis – data from an inception cohort with a disease course of two years or less (REGISPONDER-Early).  Rheumatol. 2009;  48 404-409
    CrossrefPubMedGoogle Scholar
  • 21 Roussou E, Sultana S. Spondyloarthritis in women: differences in disease onset, clinical presentation, and Bath Ankylosing Spondylitis Disease Activity and Functional indices (BASDAI and BASFI) between men and women with spondyloarthritides.  Clin Rheumatol. 2011;  30 121-127
    CrossrefPubMedGoogle Scholar
  • 22 Gensler LS, Ward MM, Reveille JD. et al . Clinical, radiographic and functional differences between juvenile-onset and adult-onset ankylosing spondylitis: results from the PSOAS cohort.  Ann Rheum Dis. 2008;  67 232-237
    PubMedGoogle Scholar
  • 23 O’Shea FD, Boyle E, Riarh R. et al . Comparison of clinical and radiographic severity of juvenile-onset versus adult-onset ankylosing spondylitis.  Ann Rheum Dis. 2009;  68 1407-1412
    CrossrefPubMedGoogle Scholar
  • 24 Stone M, Warren RW, Bruckel J. et al . Juvenile-Onset Ankylosing Spondylitis Is Associated With Worse Functional Outcomes Than Adult-Onset Ankylosing Spondylitis.  Arthritis Rheum. 2005;  53 445-451
    CrossrefPubMedGoogle Scholar
  • 25 Van der Weijden MA, van Denderen JC, Lems JC. et al . Low bone mineral density is related to male gender and decreased functional capacity in early spondyloarthropathies.  Clin Rheumatol. 2010;  Aug 10 [Epub ahead of print]
    PubMedGoogle Scholar
  • 26 Dagfinrud H, Mengshoel AM, Hagen KB. et al . Health status of patients with ankylosing spondylitis: a comparison with the general population.  Ann Rheum Dis. 2004;  63 1605-1610
    CrossrefPubMedGoogle Scholar
  • 27 Martindale J, Smith J, Sutton C. et al . Disease and psychological status in ankylosing spondylitis.  Rheumatol. 2006;  45 1288-1293
    CrossrefPubMedGoogle Scholar
  • 28 Ward MM. Health-Related Quality of Life in Ankylosing Spondylitis: A Survey of 175 Patients.  Arthritis Care Res. 1999;  12 147-155
    PubMedGoogle Scholar
  • 29 Zink A, Mau W, Schneider M. Epidemiologische und sozialmedizinische Aspekte entzündlich-rheumatischer Systemerkrankungen.  Internist. 2001;  42 211-222
    CrossrefPubMedGoogle Scholar
  • 30 Østensen M, Fuhrer L, Mathieu R. et al . A prospective study of pregnant patients with rheumatoid arthritis and ankylosing spondylitis using validated clinical instruments.  Ann Rheum Dis. 2004;  63 1212-1217
    CrossrefPubMedGoogle Scholar
  • 31 Förger F, Villiger PM, Østensen M. Pregnancy in Patients With Ankylosing Spondylitis: Do Regulatory T Cells Play a Role?.  Arthritis Rheum. 2009;  61 279-283
    CrossrefPubMedGoogle Scholar
  • 32 Boonen A, vander Cruyssen B, de Vlam K. et al . Spinal Radiographic Changes in Ankylosing Spondylitis: Association with Clinical Characteristics and Functional Outcome.  J Rheumatol. 2009;  36 1249-1255
    CrossrefPubMedGoogle Scholar
  • 33 Doran M, Brophy S, Mackay K. et al . Predictors of Longterm Outcome in Ankylosing Spondylitis.  J Rheumatol. 2003;  30 316-320
    PubMedGoogle Scholar
  • 34 Zochling J, van der Heijde D, Burgos-Vargas R. et al . ASAS/EULAR recommendations for the management of ankylosing spondylitis.  Ann Rheum Dis. 2006;  65 442-452
    CrossrefPubMedGoogle Scholar
  • 35 Huscher D, Merksdal K, Thiele K. et al . Cost of illness in rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis and systemic lupus erythematosus in Germany.  Ann Rheum Dis. 2006;  65 1175-1183
    CrossrefPubMedGoogle Scholar
  • 36 Lord PAC, Farragher TM, Lunt M. et al . Predictors of response to anti-TNF therapy in ankylosing Spondylitis: results from the British Society for Rheumatology Biologics Register.  Rheumatol. 2010;  49 563-570
    CrossrefPubMedGoogle Scholar
  • 37 Kristensen LE, Karlsson JA, Englund M. et al . Presence of peripheral arthritis and male sex predicting continuation of anti-tumor necrosis factor therapy in ankylosing Spondylitis: an observational prospective cohort study from South Swedish Arthritis Treatment Group Register.  Arthritis Care Res. 2010;  10 1362-1369
    PubMedGoogle Scholar
  • 38 Fischer-Betz RE, Schneider M. Biologika in Schwangerschaft und Stillzeit.  Z Rheumatol. 2009;  69 780-787
    PubMedGoogle Scholar
  • 39 Villinger PM, Caliezi G, Cottin V. et al . Effects of TNF antagonists on sperm characteristics in patients with Spondyloarthritis.  Ann Rheum Dis. 2010;  69 1842-1844
    CrossrefPubMedGoogle Scholar
  • 40 Boonen A, Brinkhuizen T, Landewé R. et al . Impact of ankylosing Spondylitis on sick leave, presenteeism and unpaid productivity, and estimation of the societal cost.  Ann Rheum Dis. 2010;  69 1123-1128
    CrossrefPubMedGoogle Scholar
  • 41 Zink A, Braun J, Listing J. et al . Disability and Handicap in Rheumatoid Arthritis and Ankylosing Spondylitis – Results from the German Rheumatological Database.  J Rheumatol. 2000;  613-622
    PubMedGoogle Scholar
  • 42 Boonen A, Chorus A, Miederma H. et al . Employment, work disability, and work days lost in patients with ankylosing Spondylitis: a cross sectional study of Dutch patients.  Ann Rheum Dis. 2001;  60 353-358
    CrossrefPubMedGoogle Scholar
  • 43 Mau W, Listing J, Huscher D. et al . Employment Across Chronic Inflammatory Rheumatic Diseases and Comparison with the General Population.  J Rheumatol. 2005;  32 721-728
    PubMedGoogle Scholar

Korrespondenzadresse

Dr. Uta Kiltz

Rheumazentrum Ruhrgebiet

Landgrafenstraße 15

44651 Herne

Telefon: + 49/02325/592131

Fax: + 49/02325/592136

eMail: kiltz@rheumazentrum-ruhrgebiet.de

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