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Exp Clin Endocrinol Diabetes 1989; 93(1): 90-94
DOI: 10.1055/s-0029-1210841
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Effects of Progesterone and Estradiol on Aminopeptidase A (AAP) and Leucine Aminopeptidase (LAP) Activities in the Pregnancy Serum and Placenta of the Rat

O. Kurauchi, S. Mizutani, S. Nomura, R. Hotta, Y. Ito, Y. Asada, M. Furuhashi, M. Kasugai, Y. Tomoda
  • Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Nagoya, Japan
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Publication History

1988

Publication Date:
16 July 2009 (online)

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Summary

We investigated the effects of estradiol and progesterone on placental aminopeptidase A and leucine aminopeptidase activities in pregnant rats. Estradiol (0.5, 1.0 and 2 mg/day) plus progesterone (5, 10 and 20 mg/day) was given for five days starting from the 16th day. Changes in both enzyme activities in the serum, placental cytosol and microsome caused by the steroids were analyzed. Aminopeptidase A activities in all three compartments and leucine aminopeptidase activities in the serum and cytosol were stimulated by estradiol (1.0 mg/day) plus progesterone (10 mg/day). Since we previously found that the placental aminopeptidases degrade peptide hormones, our present study suggests that steroids effect the metabolism of peptide hormones of fetal and/or maternal origin.

Key Words

Aminopeptidase A - Leucine aminopeptidase - Progesterone - Estradiol

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