Antifungal and Anthelmintic Activities of Cleistopholis patens (Annonaceae)

Abstract

Basic CH₂Cl₂ extract of the trunk bark of Cleistopholis patens (Annonaceae) exhibited antifungal activities against Candida albicans, C. parapsilosis, and C. glabrata using an agar well-diffusion assay method. Bioassay-guided fractionation of the extract led to the isolation of 8-hydroxysampangine. The methanolic extract displayed anthelmintic activity against Rhabditis pseudoelongata. Purification of the neutral CH₂Cl₂ extract yielded bornyl-p-trans-coumarate and bornyl-p-cis-coumarate.

Key words

Cleistopholis patens (Annonaceae) - 8‐hydroxysampangine - antifungal - Candida - anthelmintic - Rhabditis

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