Calcium and Pancreatic β-Cell Function: Glucose Stimulation of Uptake of Lanthanum-Displaceable ⁴⁵Ca from Low or Normal Calcium-Containing Media

Abstract

The uptake of ⁴⁵Ca was studied in β-cell-rich pancreatic islets microdissected from ob/ob-mice. Glucose stimulated ⁴⁵Ca incorporation in a lanthanum-displaceable pool remaining after correction for the extracellular space occupied by sucrose. It is suggested that the glucose effect on the lanthanum-displaceable calcium is the cause rather than the result of the secretion of insulin since it could be demonstrated also in the presence of only trace amounts of extracellular calcium.

Key words

Calcium - Lanthanum - Pancreatic Islets - Insulin Secretion