Asymmetric Transfer Hydrogenation
of Ketimines with Trichlorosilane: Structural Studies

Zhiguo Zhang; Parham Rooshenas; Heike Hausmann; Peter R. Schreiner

doi:10.1055/s-0028-1088045

SPECIALTOPIC

Asymmetric Transfer Hydrogenation of Ketimines with Trichlorosilane: Structural Studies

Zhiguo Zhang, Parham Rooshenas, Heike Hausmann, Peter R. Schreiner*
Institut für Organische Chemie, Justus-Liebig-Universität Giessen, Heinrich-Buff-Ring 58, 35392 Giessen, Germany
Fax: +49(641)9934309; e-Mail: prs@org.chemie.uni-giessen.de;

Abstract

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Abstract

We report structural and mechanistic studies on the organocatalytic asymmetric transfer hydrogenation of ketimines with trichlorosilane. Amines were obtained in good yields and moderate enantioselectivities. Both experiment and computation were utilized to provide an improved understanding of the mechanism.

Key words

amines - Lewis bases - organocatalysis - transfer hydrogenation - trichlorosilane

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References

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Supplementary Material

Supporting Information