Subscribe to RSS
DOI: 10.1055/a-2693-0621
The Infrapatellar Fat Pad Fibrosis Degree Does Not Influence Postoperative Pain 6 Months Following Patellofemoral Arthroplasty

Abstract
This retrospective study investigates whether the degree of infrapatellar fat pad (IFP) fibrosis influences postoperative pain 6 months following patellofemoral arthroplasty (PFA). Furthermore, this study explores whether sex and patellar height are impacted by the degree of IFP fibrosis. A total of 64 patients who underwent PFA from 2010 to 2023 were included, all of whom had a preoperative knee MRI and at least 1 year of follow-up. Patients were categorized into low (grades 0–1) and increased (grades 2–5) IFP fibrosis groups based on defined MRI findings. Pain outcome was assessed via a numeric rating scale. Demographic data, imaging parameters (e.g., preoperative Insall–Salvati index (IS), pre- and postoperative Caton–Deschamps index (CD), and patella morphology), and implant survivorship were analyzed. Contrary to the hypothesis, no significant association was found between IFP fibrosis degree and postoperative pain levels 6 months following PFA. Notably, the low IFP fibrosis group had a significantly higher prevalence of females (p = 0.02) and a higher preoperative IS index (p < 0.05), suggesting a connection among IFP fibrosis status, sex, and patellar height. No differences between groups were observed in age, body mass index, delta CD index, patella type, or implant survivorship. The lack of association between IFP fibrosis and postoperative pain suggests that IFP fibrosis may not be a determinant of PFA outcomes, potentially guiding surgeons to focus on other factors for optimizing postoperative pain management and implant success. Further studies are needed to elucidate the roles of sex and patellar height in the development of IFP fibrosis. The study provides level III evidence.
Keywords
patellofemoral arthroplasty - infrapatellar fat pad - fibrosis - pain - knee osteoarthritisContributors' Statement
Research design and drafting: D.F. Data acquisition, analysis, and interpretation: D.F. and C.B.G.L. Revising: D.F., C.B.G.L., S.S., M.T.D.S., N.S., O.P., C.J., and C.L. All authors have read and approved the final submitted manuscript.
Publication History
Received: 30 May 2025
Accepted: 30 August 2025
Accepted Manuscript online:
01 September 2025
Article published online:
11 September 2025
© 2025. Thieme. All rights reserved.
Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA
-
References
- 1 Pacchiarotti G, Todesca A, Coppola M, Gumina S. Robotic-assisted patellofemoral arthroplasty provides excellent implant survivorship and high patient satisfaction at mid-term follow-up. Int Orthop 2024; 48 (08) 2055-2063
- 2 Yang Y, Chen Y, Wang Y. et al. The landscape of patellofemoral arthroplasty research: a bibliometric analysis. Arthroplasty 2023; 5 (01) 65
- 3 Yamawaki Y, Kuriyama S, Watanabe M, Nakamura S, Ohkoshi Y, Matsuda S. Internal rotation, varus, and anterior femoral component malalignments adversely affect patellofemoral joint kinematics in patellofemoral arthroplasty. Arthroplast Today 2023; 21: 101124
- 4 Farr II J, Barrett D. Optimizing patellofemoral arthroplasty. Knee 2008; 15 (05) 339-347
- 5 Dye SF, Vaupel GL, Dye CC. Conscious neurosensory mapping of the internal structures of the human knee without intraarticular anesthesia. Am J Sports Med 1998; 26 (06) 773-777
- 6 Bohnsack M, Meier F, Walter GF. et al. Distribution of substance-P nerves inside the infrapatellar fat pad and the adjacent synovial tissue: a neurohistological approach to anterior knee pain syndrome. Arch Orthop Trauma Surg 2005; 125 (09) 592-597
- 7 Gallagher J, Tierney P, Murray P, O'Brien M. The infrapatellar fat pad: anatomy and clinical correlations. Knee Surg Sports Traumatol Arthrosc 2005; 13 (04) 268-272
- 8 Stephen JM, Sopher R, Tullie S, Amis AA, Ball S, Williams A. The infrapatellar fat pad is a dynamic and mobile structure, which deforms during knee motion, and has proximal extensions which wrap around the patella. Knee Surg Sports Traumatol Arthrosc 2018; 26 (11) 3515-3524
- 9 Leese J, Davies DC. An investigation of the anatomy of the infrapatellar fat pad and its possible involvement in anterior pain syndrome: a cadaveric study. J Anat 2020; 237 (01) 20-28
- 10 Fontanella CG, Macchi V, Carniel EL. et al. Biomechanical behavior of Hoffa's fat pad in healthy and osteoarthritic conditions: histological and mechanical investigations. Australas Phys Eng Sci Med 2018; 41 (03) 657-667
- 11 Nakagawa Y, Tsuji K, Nakamura T. et al. Association of infrapatellar fat pad fibrosis at 3 months after ACL reconstruction with short-term clinical outcomes and inflammatory cytokine levels in the synovial fluid. Orthop J Sports Med 2023; 11 (04) 23 259671231164122
- 12 Macchi V, Porzionato A, Sarasin G. et al. The infrapatellar adipose body: a histotopographic study. Cells Tissues Organs 2016; 201 (03) 220-231
- 13 Inomata K, Tsuji K, Onuma H. et al. Time course analyses of structural changes in the infrapatellar fat pad and synovial membrane during inflammation-induced persistent pain development in rat knee joint. BMC Musculoskelet Disord 2019; 20 (01) 8
- 14 Hoshino T, Tsuji K, Onuma H. et al. Persistent synovial inflammation plays important roles in persistent pain development in the rat knee before cartilage degradation reaches the subchondral bone. BMC Musculoskelet Disord 2018; 19 (01) 291
- 15 An JS, Tsuji K, Onuma H. et al. Inhibition of fibrotic changes in infrapatellar fat pad alleviates persistent pain and articular cartilage degeneration in monoiodoacetic acid-induced rat arthritis model. Osteoarthritis Cartilage 2021; 29 (03) 380-388
- 16 Onuma H, Tsuji K, Hoshino T. et al. Fibrotic changes in the infrapatellar fat pad induce new vessel formation and sensory nerve fiber endings that associate prolonged pain. J Orthop Res 2020; 38 (06) 1296-1306
- 17 Tanaka N, Sakahashi H, Sato E, Hirose K, Isima T. Influence of the infrapatellar fat pad resection in a synovectomy during total knee arthroplasty in patients with rheumatoid arthritis. J Arthroplasty 2003; 18 (07) 897-902
- 18 Pinsornsak P, Naratrikun K, Chumchuen S. The effect of infrapatellar fat pad excision on complications after minimally invasive TKA: a randomized controlled trial. Clin Orthop Relat Res 2014; 472 (02) 695-701
- 19 Satake Y, Izumi M, Aso K, Ikeuchi M. Association between infrapatellar fat pad ultrasound elasticity and anterior knee pain in patients with knee osteoarthritis. Sci Rep 2023; 13 (01) 20103
- 20 Walker H, Rao A, Tsimiklis J, Smitham P. Are short term outcomes superior following total knee arthroplasty when infra-patellar fat pad is resected? A systematic review and meta-analysis. ANZ J Surg 2024; 94 (7-8): 1234-1239
- 21 Verhulst FV, van Sambeeck JDP, Olthuis GS, van der Ree J, Koëter S. Patellar height measurements: Insall-Salvati ratio is most reliable method. Knee Surg Sports Traumatol Arthrosc 2020; 28 (03) 869-875
- 22 Yue RA, Arendt EA, Tompkins MA. Patellar height measurements on radiograph and magnetic resonance imaging in patellar instability and control patients. J Knee Surg 2017; 30 (09) 943-950
- 23 Wibeeg G. Roentgenographs and anatomic studies on the femoropatellar joint: with special reference to chondromalacia patellae. Acta Orthop Scand 1941; 12 (1–4): 319-410
- 24 Koo TK, Li MY. A guideline of selecting and reporting intraclass correlation coefficients for reliability research. J Chiropr Med 2016; 15 (02) 155-163
- 25 Sun K, Tordjman J, Clément K, Scherer PE. Fibrosis and adipose tissue dysfunction. Cell Metab 2013; 18 (04) 470-477
- 26 Householder LA, Comisford R, Duran-Ortiz S. et al. Increased fibrosis: a novel means by which GH influences white adipose tissue function. Growth Horm IGF Res 2018; 39: 45-53
- 27 Carver W, Esch AM, Fowlkes V, Goldsmith EC. The Biomechanical Environment and Impact on Tissue Fibrosis. In: The Immune Response to Implanted Materials and Devices. Springer International Publishing; 2017: 169-188
- 28 Davis KED, D. Neinast M, Sun K. et al. The sexually dimorphic role of adipose and adipocyte estrogen receptors in modulating adipose tissue expansion, inflammation, and fibrosis. Mol Metab 2013; 2 (03) 227-242
- 29 Andrish J. The biomechanics of patellofemoral stability. J Knee Surg 2004; 17 (01) 35-39
- 30 Diaz-Martinez NF, Pulgarin-Giraldo JD, Vinasco-Isaza LE, Agredo W. Analysis of the alignment angles and flexion angle in women with patellofemoral pain syndrome. In: 2017: 666-669
- 31 Mizuno Y, Kumagai M, Mattessich SM. et al. Q-angle influences tibiofemoral and patellofemoral kinematics. J Orthop Res 2001; 19 (05) 834-840
- 32 Fransson EI, Batty GD, Tabák AG. et al. Association between change in body composition and change in inflammatory markers: an 11-year follow-up in the Whitehall II study. J Clin Endocrinol Metab 2010; 95 (12) 5370-5374
- 33 Zhao J, Cao X, Li Q, Xie J, Wu H. Obesity mediates the association between serum copper and inflammation: a cross-sectional and mendelian randomization study. Biol Trace Elem Res 2024;
- 34 Davulcu C, Celayir A. Exploring the correlation between body mass index and knee Hoffa fat pad size in MRI sagittal plane. Ann Med Res 2024; 1
- 35 McNamara NE, Shing EZ, Khalil AZ. et al. Tibial tubercle osteotomy with and without medial patellofemoral ligament reconstruction in adolescent patients leads to decrease in patellar height and patella tendon length. J Pediatr Orthop 2024; 44 (09) e773-e781
- 36 Kreulen RT, Anderson G, Yalcin S. et al. Evaluation of differences in patellar height after patellar stabilization procedures not intended to address patella alta: a multicenter study. Orthop J Sports Med 2024; 12 (03) 23 259671241235597