Core GRADE für Evidenzsynthesen

GRADE is a globally recognized approach for assessing the certainty of evidence (also: quality or certainty of evidence) and formulating recommendations in systematic reviews, guidelines and other evidence syntheses. GRADE (Grading of Recommendations Assessment, Development and Evaluation) was introduced approximately 20 years ago by an international working group led by Canadian physician Gordon Guyatt, one of the pioneers of evidence-based practice [1]. GRADE has evolved continuously over time and has now reached a high level of complexity. In the context of the strengths and weaknesses of the established GRADE concept, the Core GRADE approach recently presented by Guyatt et al. represents a significant development, which should lead to simpler and more frequent use of GRADE [2]. The new Core GRADE approach is described in detail in a 7-part series of articles and is highly relevant to physiotherapy science [2].

Publikationsverlauf

Artikel online veröffentlicht:
08. Dezember 2025

• References

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• 19 Guyatt G, Zeng L, Brignardello-Petersen R. et al. Core GRADE 2: choosing the target of certainty rating and assessing imprecision. BMJ 2025; 389: e081904
• 20 Guyatt G, Schandelmaier S, Brignardello-Petersen R. et al. Core GRADE 3: rating certainty of evidence-assessing inconsistency. BMJ 2025; 389: e081905
• 21 Guyatt G, Wang Y, Eachempati P. et al. Core GRADE 4: rating certainty of evidence-risk of bias, publication bias, and reasons for rating up certainty. BMJ 2025; 389: e083864
• 22 Guyatt G, Iorio A, Beer H de. et al. Core GRADE 5: rating certainty of evidence-assessing indirectness. BMJ 2025; 389: e083865
• 23 Guyatt G, Yao L, Murad MH. et al. Core GRADE 6: presenting the evidence in summary of findings tables. BMJ 2025; 389: e083866
• 24 Guyatt G, Vandvik PO, Iorio A. et al. Core GRADE 7: principles for moving from evidence to recommendations and decisions. BMJ 2025; 389: e083867