Beeinflussung der Sterblichkeit bei älteren Menschen durch Selen und Q10

Zusammenfassung

Die orthomolekulare Medizin wird von der konventionellen Medizin immer noch belächelt, teilweise sogar als unwirksam oder schädlich bekämpft. Besonders das Fehlen von überzeugenden Studien wird kritisiert. Vor einigen Jahren wurden aber die Ergebnisse einer randomisierten, doppelblinden Interventionsstudie publiziert, die eine Halbierung der Sterblichkeit in der Verumgruppe aufzeigte. Wegen der großen Bedeutung für die orthomolekulare Medizin im Allgemeinen und die Lebenserwartung und die Lebensqualität bei älteren Menschen im Besonderen sollen die Ergebnisse dieser Studie hier im Einzelnen vorgestellt werden.

Abstract

Orthomolecular medicine is still being ridiculed by conventional medicine, sometimes even fought as ineffective or harmful. Especially the lack of convincing studies is criticized. However, several years ago, the results of a randomized, double-blind intervention study were published, which showed a halving of mortality in the active treatment group. Because of the great importance for orthomolecular medicine in general and the life expectancy and quality of life of older people in particular, the results of this study will be presented in detail here.

Schlüsselwörter

Selen - Coenzym Q10 - kardiovaskuläre Mortalität - KHK - Lebensqualität

Key words

Selenium - coenzyme q10 - cardiovascular mortality - coronary heart disease - quality of life

• Literatur

• 1 Alehagen U, Aaseth J, Alexander J. et al. Less fibrosis in elderly subjects supplemented with selenium and coenzyme Q10-A mechanism behind reduced cardiovascular mortality?. Biofactors 2018; 44 (02) 137-147
• 2 Alehagen U, Aaseth J, Alexander J. et al. Still reduced cardiovascular mortality 12 years after supplementation with selenium and coenzyme Q10 for four years: A validation of previous 10-year follow-up results of a prospective randomized double-blind placebo-controlled trial in elderly. PLoS One 2018; 13 (04) e0193120 doi: 10.1371/journal.pone.0193120
• 3 Alehagen U, Aaseth J, Johansson P. Less increase of copeptin and MR-roADM due to intervention with selenium and coenzyme Q10 combined: Results from a 4-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. Biofactors 2015; 41 (06) 443-452
• 4 Alehagen U, Aaseth J, Johansson P. Reduced cardiovascular mortality 10 years after supplementation with selenium and coenzyme Q10 for four years: Follow-up results of a prospective randomized double-blind placebo-controlled trial in elderly citizens. PLoS One 2015; 10 (12) e0141641 doi: 10.1371/journal.pone.0141641
• 5 Alehagen U, Alexander J, Aaseth J. Supplementation with selenium and coenzyme Q10 reduces cardiovascular mortality in elderly with low selenium status. A secondary analysis of a randomised clinical trial. PLoS One 01.07.2016; 11 (07) e0157541 doi: 10.1371/journal.pone.0157541
• 6 Alehagen U, Johansson P, Aaseth J. et al. Significant changes in circulating microRNA by dietary supplementation of selenium and coenzyme Q10 in healthy elderly males. A subgroup analysis of a prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. PLoS One 2017; 12 (04) e0174880 doi: 10.1371/journal.pone.0174880
• 7 Alehagen U, Johansson P, Björnstedt M. et al. Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: A 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. Int J Cardiol 2013; 167 (05) 1860-1866
• 8 Alehagen U, Johansson P, Björnstedt M. et al. Relatively high mortality risk in elderly Swedish subjects with low selenium status. Eur J Clin Nutr 2016; 70 (01) 91-96
• 9 Alehagen U, Lindahl TL, Aaseth J. et al. Levels of sP-selectin and hs-CRP decrease with dietary intervention with selenium and coenzyme Q10 combined: A secondary analysis of a randomized clinical trial. PLoS One 2015; 10 (09) e0137680 doi: 10.1371/journal.pone.0137680
• 10 Johansson P, Dahlström Ö, Dahlström U. et al. Effect of selenium and Q10 on the cardiac biomarker NT-proBNP. Scand Cardiovasc J 2013; 47 (05) 281-288
• 11 Johansson P, Dahlström Ö, Dahlström U. et al. Improved health-related quality of life, and more days out of hospital with supplementation with selenium and coenzyme Q10 combined. Results from a double blind, placebo-controlled prospective study. J Nutr Health Aging 2015; 19 (09) 870-877
• 12 Mortensen SA, Rosenfeldt F, Kumar A. et al. Q-SYMBIO Study Investigators: The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: Results from Q-SYMBIO: a randomized double-blind trial. JACC Heart Fail 2014; 2 (06) 641-649