A model to evaluate mucosal flow in ulcerative colitis by laser Doppler flowmetry

G. Gizzi; L. Pellegrini; G. Laurora; M. R. Cesarone; G. Belcaro; L. Barbara

doi:10.1007/BF02651521

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Int J Angiol 1992; 1(2): 86-92
DOI: 10.1007/BF02651521

Original Articles

A model to evaluate mucosal flow in ulcerative colitis by laser Doppler flowmetry

G. Gizzi¹ , L. Pellegrini² , G. Laurora² , M. R. Cesarone² , G. Belcaro³ , L. Barbara

¹The Departments of Medicine and Gastroenterology, Policlinico S. Orsola, Bologna
²The Microcirculation Laboratory, Cardiovascular Clinic, G. D'Annunzio University, Chieti, Italy
³The Irvine Laboratory for Investigation and Research, St. Mary's Hospital, London, England

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Publication History

Publication Date:
22 April 2011 (online)

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Abstract

Endoscopic laser-Doppler flowmetry was used to evaluate the mucosal skin blood flow in the terminal part of the sigmoid colon in 7 patients with ulcerative colitis and in 8 normals subjects. In total, 229 observations were made. A MUSK (mucosal-skin blood) flow index was obtained that was able to differentiate the normal from abnormal mucosa and areas with different endoscopic characteristics.

The evaluation of mucosal skin blood flow is reproducible, correlated with the local clinical appearance, and relatively simple, and it can be used to evaluate mucosal flow.