Predictive factors for the removal of “soft” femoropopliteal occlusions with intraarterial short-term and high-dose urokinase treatment

Abstract

To date, intraarterial lysis is a widely accepted form of treatment for femoropopliteal occlusions. However, the outcome of therapy has been difficult to predict. Therefore, the present study dealt with two parameters likely to influence the occlusion removal rate. These are the outflow condition distal of the occlusion, and the occlusion length. Fifty patients with subacute femoropopliteal occlusions were treated with intraarterial thrombolysis and, in case residual obstructions were left, with subsequent catheter dilation. Only “soft” occlusions that were probed by a guide wire and proved to be penetrable were chosen for treatment. The occlusion age was 3.79±4.57 weeks with 90% of cases in the range of 1 day to 6 weeks. Fibrinolytic therapy consisted of one to three one-hour series of 300,000 IU urokinase instillation directly into the occlusion material. The complete clearance rate was 34/50 = 68%. In successfully treated patients, both the pressure gradient (difference between systemic and ankle pressure) and the walking distance improved significantly. Most important factors for success or failure of treatment were the quality of calf outflow and the length of obstruction. Thus, patients with at least one calf artery open and an occlusion length of under 10 cm presented with an opening rate of 88.5%, whereas patients with no calf arteries patent and an occlusion length over 20 cm presented with an opening rate of only 20%. The age of the occlusions, all penetrable by a guide wire prior to treatment, did not influence the rate of recanalization. Intraarterial short-term and high-dose urokinase infusion is an excellent form of treatment for subacute femoropopliteal occlusions. Especially good results with a 88.5% clearance rate were achieved in patients who presented with at least one calf artery open and an occlusion length below 10 cm.