DOI: 10.1055/s-00000131

Synfacts

Ausgabe 08 · Volume 18 · August 2022 DOI: 10.1055/s-012-54347

Synform

A118
SYNFORM ISSUE 2022/08

Synthesis of Natural Products and Potential Drugs

z0825
All PDFs of this category
0825
Synthesis of Furaprevir
0826
Synthesis of (–)-Flueggeacosine B
0827
Total Synthesis of (+)-Ribostamycin
0828
Synthesis of BMS-963272
0829
Synthesis of Rucaparib
0830
Total Synthesis of (–)-Normacusine B
0831
Synthesis of (–)-Voacinol and (–)-Voacandimine C
0832
Synthesis of Navoximod
0833
Synthesis of Deucravacitinib
0834
Total Synthesis of Four Lycopodium Alkaloids
0835
Synthesis of Branebrutinib
0836
Total Synthesis of (–)-Octanorcucurbitacin B
0837
Synthesis of (±)-Longifolene
0838
Synthesis of a Noncovalent Oral SARS-CoV-2 3CL Protease Inhibitor

Synthesis of Heterocycles

z0839
All PDFs of this category
0839
Efficient Functionalization of Aminocyclopropanes
0840
Precious-Metal-Free One-Pot Synthesis of Imidazopyridines and Thiazoles
0841
Highly Regioselective Cross-Coupling of Dihalohetarenes
0842
Ruthenium-Catalyzed Synthesis of Isoquinolinones from Allenylphosphine Oxides and Aromatic Amides
0843
Diastereo- and Enantioselective trans-Hydrogenation of Isoquinolines
0844
Brønsted Acid Mediated Synthesis of 1,4-Dioxanes
0845
Ketoreductase-Mediated Dynamic Kinetic Resolution
0846
Sustainable and Scalable Approach to 5-Substituted-1H-Tetrazoles
0847
ortho-Selective C(sp2)–H Borylation of Pyridines with an Yttrocene Catalyst
0848
Preparation of Diazacyclobutenes by a Lewis Acid Catalyzed [2+2] Cycloaddition
0849
Efficient Synthesis of Versatile Furopyridines from Acyclic Precursors
0850
Photochemical Metal-Free Coupling Reactions for Pyridine-Derived Small Molecules and DNA Conjugates
0851
Synthesis of 2-Benzoxazoles by DMF-Assisted Radical Cyclization of o-Isocyanodiaryl Ethers
0852
Efficient Merging of Proven Pharmacophores

Synthesis of Materials and Unnatural Products

z0853
All PDFs of this category
0853
Double, Double, Toil, and Thieno-Fused Coronene Nanoribbons
0854
Towards Large Acenes with B–N Pair Doping
0855
Ben[a]azulene Bonanza
0856
Nanographene Switches for NHC Ligands
0857
Decorating Soccer Balls
0858
Pyracylene Boats
0859
Organo-cyclosilanes for Hybrid Conjugation Materials
0860
Expansion of Curved π-Network
0861
π-Extension Granted to TADF Emitters
0862
Cumulating [5]Cumulenes and Hexaphenylbenzenes
0863
Terrylene Diimide with Carbazole Wings
0864
Zirconocenes and Cyclobutadienes and Copper(III), Oh My!

Metals in Synthesis

z0865
All PDFs of this category
0865
Switchable Selectivity in Pd-Catalyzed Lactonization via Ligand-Controlled Regioselective C–H Activation
0866
Rh-Catalyzed Hydrogenative One-Pot Protocol for the Synthesis of Saturated N-Heterocycles
0867
Take Et instead of Me: Preparation and Application of a Novel Class of Stable Arylboronic Esters
0868
Palladium-Catalyzed Domino Narasaka–Heck/C–H Activation Reaction Generating Spirocyclic Pyrrolines
0869
Palladium-Catalyzed Regiodivergent Decarboxylative Hydrothiocarbonylation of Alkenes
0870
Copper-Catalyzed Asymmetric Borylative Cross-Coupling of Enynes and Alkylidene Malonates
0871
Nickel-Catalyzed C–S Bond Formation using Thiols as the Sulfur Source
0872
Reductive Ring Opening of Epoxides under Dual Zirconocene and Photoredox Catalysis
0873
When Strong Brønsted Acids Fail: Hydroalkoxylation of Unactivated Alkenes under Triple Catalysis
0874
Diastereo- and Enantioselective Pinacol Coupling under Dual Titanium and Photoredox Catalysis
0875
Synthesis of Allylic Alcohols by Ruthenium-Catalyzed Asymmetric Addition of Primary Alcohols to 2-Butyne
0876
Selective Reduction of 2° Amides to Imines Catalyzed by Schwartz’s Reagent
0877
Use of Amidyl Radicals to Enable Remote Arylation of C(sp3)–H Bonds via Nickel Catalysis
0878
Synthesis of Quinazolines via Palladium-Catalyzed Acceptorless Double Dehydrogenation
0879
Rhodium-Catalyzed Enantio- and Diastereoselective Synthesis of Alkylidenecyclopropanes
0880
Palladium-Catalyzed Asymmetric Hydrooxygenation of Terminal Alkenes
0881
Dehydrogenative Asymmetric Allylic Alkylation via Ternary Catalysis
0882
Ni-Catalyzed Asymmetric Hydroarylation of Alkenes Under Chain-Walking by Multiligand-Relay Catalysis
0883
Take it Easy: Convenient Preparation of Dicarbamoyl-zincs for the Synthesis of Polyfunctionalized Amides
0884
Palladium-Catalyzed Enantioselective Bis-carboxylation Reaction of Alkynes
0885
Reversible C–S Bond Activation – Accessing Thiolated Heterocycles via Palladium Catalysis
0886
Enantioselective Synthesis of Azabicyclo[3.1.0]-hexanes via Sequential CpxRh and Cp*Ir Catalysis
0887
Copper-Catalyzed Halodecarboxylation of (Hetero)aryl Carboxylic Acids
0888
A Palladium-Catalyzed Ring-Expansion Strategy to Access Dibenzoazepines from Indoles
0889
Palladium-Catalyzed Oxidative Cross-Coupling of Two Alkenes Using tert-Leucine as Transient Directing Group
0890
Access to Enantioenriched Lactones by Copper-Catalyzed Carboesterification of Styrenes
0891
The Liebeskind–Srogl Cross-Coupling

Polymer-Supported Synthesis

z0893
All PDFs of this category
0893
Photocatalytic C–N Cross-Coupling by a Covalent Organic Framework Containing Iridium and Nickel
0894
1,4-Addition of Arylboronic Acids to Unsaturated Ketones by Rh Complexes on Mesoporous Silica
0895
Cycloaddition of Propargylic Alcohols and Amines to Carbon Dioxide On Supported Cu2O Nanoparticles
0896
Hydrogenation of Aldehydes, Ketones, and Nitroarenes on Mesoporous Silica-Encapsulated Cu Clusters
0897
Photocatalytic Oxidation of Sulfides on Silver-Based Coordination Polymers
0898
Synthesis of Thiophosphinates from Phosphine Oxides and Thiols Using a Photoactive COF
0899
Gold(I)-Catalyzed Synthesis of Benzo[b]oxepine and Benzo[b]azepine
0900
Ring-Opening of Styrene Oxide and Cyclohexane Oxide with Amines by SrFe19O12 on Graphene Oxide
0901
Oxidative Methyl Esterification of Ketones Promoted by an N-Doped Carbon Nanosheet
0902
Electrochemical Semihydrogenation of Alkynes to Alkenes on Pd–Fe Nanosheet Catalysts
0903
Aerobic Oxidation of Amines to Imines by Single Atomic Fe Catalysts with Coexisting Fe Nanoclusters

Organo- and Biocatalysis

z0905
All PDFs of this category
0905
Light-Initiated Hydrogen Atom Transfer-Driven Asymmetric Minisci Reaction of Primary Alcohols
0906
Enantioselective Catalytic Sulfenofunctionalization of Nonactivated Cyclic and (Z)-Alkenes
0907
Enhanced Lewis Acidity of Diarylnaphthotriazinium Salts Permits Hydrosilylation of Imines
0908
Organophotoredox Catalyst for a Decarboxylative and Alkylative Semipinacol-Type Rearrangement
0909
Iodoresorcinol-Based Organocatalysts Permit Stereocontrolled Synthesis of Fluoroisochromans
0910
Phosphetane Organocatalyst Permits Reductive C–N Coupling of Nitroalkanes with Arylboronic Acids
0911
Organophotocatalytic Copolymerization of Perfluorinated Vinyl Ethers
0912
Chiral Brønsted Base-Catalyzed [8+3]-Cycloaddition Reaction of Donor–Acceptor Cyclopropanes
0913
Strong and Confined Acid-Catalyzed Asymmetric Synthesis of Silyl Ethers Bearing a Stereogenic Silicon
0914
Asymmetric Cyanosilylation of Small Ketones

Chemistry in Medicine and Biology

z0915
All PDFs of this category
0915
Synthesis and Biological Evaluation of Alkaloid GB18
0916
Expanding Horizons: Piperazinobenzodiazepinones as Alphavirus Inhibitors
0917
Targeted Chemotherapy Using in Vivo Transition Metal Catalysis
0918
Is Further Rhodamine Functionalization Beneficial? Si
0919
Synthesis of Bioactive Euphane Triterpenoid System
0920
Extracting Unique Structures from Nature: A Potential anti-Covid Agent Synthesis
0921
Synthesis of MK-2305 via Enantioselective Hydrogenation of a Tetrasubstituted Olefin
0922
A Potent Allosteric Inhibitor of HIV-1 Integrase
0923
Optimized Oxazocine Inhibitor of Mutant KRASG12C
0924
Fluorescent BODIPY Caged by Azobenzene
0925
The Hidden Symmetry of (±)-Histrionicotoxin

Peptide Chemistry

z0927
All PDFs of this category
0927
Palladium/Copper-Catalyzed Synthesis of α-Alkenyl α-Amino Acids from 2-Fluoro-1,3-dienes
0928
Synthesis of Peptide α-Keto Acids and Application to Decarboxylative Peptide Coupling
0929
Ruthenium-Catalyzed Late-Stage C–H Acyloxylation of Peptides
0930
Dual-Protein-Catalyzed Site-Selective Deuteration
0931
Peptide Bond Formation Mediated by Thionyl Fluoride
0932
Electrocarbonylation of N-Acylimines with Atmospheric Carbon Dioxide
0933
Post-Translational Modifications of Dehydroalanine: Synthesis of Asparagine Derivatives
0934
Iridium-Catalyzed Asymmetric N-Allylation of Amino Acids
0935
Synthesis of Optically Active β- or γ-Amino Acid Derivatives
0936
Expeditious Deprotection of N-Benzyloxycarbonyl and N-Benzyl Derivatives

Flow Chemistry

z0937
All PDFs of this category
0937
Preparation of Organosodium Compounds by Flow System
0938
Diastereoselective Synthesis of α-Chiral Piperidines in Flow
0939
Synthesis of Unsymmetrically Substituted Phosphites and Phosphates Using a Flow System
0940
Synthesis of Disulfides under Flow Conditions