DOI: 10.1055/s-00000131

Synfacts

Issue 04 · Volume 16 · April 2020 DOI: 10.1055/s-010-46169

Synform

A51
Zanda, Matteo: SYNFORM ISSUE 2020/04

Synthesis of Natural Products and Potential Drugs

z0371
All PDFs of this category
0371
Synthesis of an Indoleamine-2,3-dioxygenase-1 (IDO1) Inhibitor
0372
Total Synthesis of (–)-Cymoside
0373
Total Synthesis of (+)-Corymine and (–)-Deformylcorymine
0374
Synthesis of (–)-FD-594
0375
Total Syntheses of ent-Kaurane Diterpenoids
0376
Synthesis of Aztreonam
0377
Total Synthesis of Tetrodotoxin
0378
Synthesis of Simurosertib (TAK-931)
0379
Synthesis of (–)-Pepluanol B
0380
Synthesis of BMS-986260
0381
Synthesis of (±)-Saudin

Synthesis of Heterocycles

z0383
All PDFs of this category
0383
2-Arylpiperidines by Palladium-Catalyzed Addition of Arylboronic Acids to Acylated 2-Hydroxypiperidines
0384
Synthesis of Phosphorylpyrroloindoles by Photocatalytic Phosphinoylation/Cyclization Reactions
0385
Synthesis of Thiochromenes by Palladium-Catalyzed Ring Opening of Cyclopropyl Thioethers
0386
Regioselective Synthesis of Polyfluorinated o-Hydroxyacetophenones
0387
Chemodivergent and Enantiospecific Synthesis of Benzazepines and Allyl Fluorides
0388
Organocatalyzed Synthesis of Fully Substituted Furans from Ynamides and Quinoxaline N-Oxides
0389
Diastereoselective De Novo Synthesis of Functionalized Piperidines
0390
Construction of Highly Substituted Furans and Thiophenes with Sulfur Ylides
0391
C(sp3)–H Functionalization of Aliphatic Acids through β-Lactonization
0392
Asymmetric Copper-Catalyzed Synthesis of Dihydrobenzofuran-3-ols
0393
Palladium(II)-Catalyzed Synthesis of Tribenzo[b,d,f]azepines
0394
Three-Component Synthesis of 3-(Trifluoromethyl)pyrazoles
0395
Base-Promoted Annulations in the Synthesis of Ring-Fused N-Substituted-4-Quinolinones

Synthesis of Materials and Unnatural Products

z0397
All PDFs of this category
0397
Approaching a Pyridine by Aza-APEX
0398
All Aboard the EBXpress to Dithioalkenes
0399
Put Phosphorus in Your Rhodamine
0400
From Simple to Complex: One-Pot Synthesis of Dimeric Pyrrolo-Fused Isoquinolines
0401
Spin Me Right Round: Spirocyclic Organic Electronic Materials
0402
Fountain of Pyrenes
0403
Lighting Up Helicenes
0404
Small Helicenes, Big Deal
0405
Party of Rotaxanes
0406
Ion Pair Receptors: Bambusuril–Crown Ether Conjugates
0407
‘A One and A Two’: Orchestrating Polymer Backbone Breakdown
0408
Expansion of Coumarins by One-Pot Synthesis

Metals in Synthesis

z0409
All PDFs of this category
0409
Bismuth Redox-Catalyzed Fluorination of Arylboron Reagents
0410
A Diastereo- and Enantioselective Copper-Catalyzed Allylation of Imines Using Allylic gem-Diboron Reagents
0411
Palladium-Catalyzed γ-C(sp3)–H Bond Activation of Tertiary Alkyl Amines
0412
Coupling Reactions of Aldehydes and Hydrocarbons
0413
Synthesis of Conjugated 1,3-Diynes
0414
Aryl Thioether Metathesis under Nickel Catalysis
0415
Enantioselective Preparation of Propargyl Amides
0416
Axially Chiral 2,3-Disubstituted Indoles via Palladium-Catalyzed Enantioselective Cacchi Reaction
0417
Copper-Catalyzed Coupling of Remote C(sp3)–H Bonds with Terminal Alkynes
0418
meta-Selective Inverse Sonogashira Coupling
0419
Nickel-Catalyzed Carboxylation of Arylsulfonium Salts Using CO2
0420
Palladium-Catalyzed Asymmetric Cycloadditions
0421
C–H Functionalization of Alkenes
0422
Enantioselective Rhodium-Catalyzed Hydroformylation of α-Substituted Acryl Acid Derivatives
0423
Photocatalytic Umpolung Strain-Release Amino-Functionalization of [1.1.1]-Propellanes
0424
Transthioetherification of Aryl Halides with Thioethers or Thioesters under Palladium Catalysis
0425
Stereodivergent Allylic Alkylation/Fluorination of Acyclic Ketones
0426
Dual Catalysis: Photoredox/Chromium-Catalyzed Dialkylation of 1,3-Dienes
0427
Chromium/Iridium-Photoredox Dual-Catalyzed Formal Addition of α-Amino Carbanions to Carbonyls
0428
Hydroamination of Alkenes
0429
Radical Cascade Synthesis of Azoles
0430
Nickel-Catalyzed Reductive Acylation of Aliphatic Amines
0431
Intermolecular Palladium-Catalyzed Atropo-Enantioselective C–H Arylation of Heteroarenes
0432
Synthesis of 1,3-Dienes by a Photoinduced C(sp2)−H/C(sp2)−H Cross-Coupling of Alkenes
0433
Fused Tricyclic Hydronaphthofurans through Rhodium-Catalyzed Desymmetrization
0434
Scandium-Catalyzed Enantioselective C–H Transfer Across an Alkene
0435
Low Catalyst Loading: Rhodium(II)-Catalyzed Asymmetric Cyclopropanation
0436
Photoredox-Catalyzed Benzylic C–H Activation and Coupling with Aldehydes
0437
The Corey–House Reaction: An Early Transition-Metal-Mediated Cross-Coupling

Polymer-Supported Synthesis

z0439
All PDFs of this category
0439
Photocatalytic C–H Alkylation of Quinoxalin-2-ones on a Covalent Organic Framework
0440
Palladium/Alumina-Catalyzed Decarbonylative Aldol Condensation of Aldehydes
0441
Photocatalytic Oxidative Coupling of Benzylamines on a Hydrazone-Based Covalent Organic Framework
0442
A Zirconium–Tannin Hybrid Catalyst for Meerwein–Ponndorf–Verley Reduction
0443
Reductive Amination of 5-(Hydroxymethyl)furfural on Immobilized Palladium Nanoparticles
0444
C–C, C–O, C–S, and C–N Bond Formation from Diazo Compounds on Mesoporous Silica-Supported Triflic Acid
0445
Silver Nanoparticle Catalyzed Selective Reduction of Nitro Compounds and Nitriles
0446
Aza-Semipinacol Rearrangement Catalyzed by Graphene Oxide
0447
Flow Esterification on a Second-Generation m-Phenolsulfonic Acid–Formaldehyde Resin Catalyst
0448
Reduction of Aryl Ketones and Aldehydes to Hydrocarbons Catalyzed by Palladium/Carbon
0449
CuMoO4 Nanoparticles-Catalyzed Cross-Coupling of Aryl Halides with Thiols
0450
One-Pot Sequential Cross-Aldol Condensation/Aza-Michael Addition on Graphene Oxide
0451
Dehydrogenation of NH–NH Bonds Catalyzed by Ni–Fe Supported on N-Doped Carbon from Chitosan

Organo- and Biocatalysis

z0453
All PDFs of this category
0453
Pot-Economic Organocatalytic Asymmetric Synthesis of the Corey Lactone
0454
Superbase-Catalyzed Enantioselective Aldol Addition of Aryl Ketones to α-Fluorinated Ketones
0455
A Modified Tripeptide Catalyst Changes Conventional Diastereoselectivity in Michael Additions
0456
Organic Single-Electron Reductants Permit Photocatalytic Borylation of C–O, C–N, and C–X Bonds
0457
N-Functionalized Azaheterocycles through PIII/PV=O-Catalyzed Cascade Synthesis
0458
NHC-Catalyzed Generation of p-Quinodimethanes through ε-Umpolung: Nucleophilic Addition to Ketones
0459
Two Distinct Hydrogen Atom Transfer Steps Permit Selective Epimerization of Pyranose Frameworks
0460
NHC-Catalyzed Umpolung Approach Toward Heteroaryl Ynones
0461
Reductive Electrophotocatalysis

Chemistry in Medicine and Biology

z0463
All PDFs of this category
0463
RIBOTACs – Targeted Degradation of RNA
0464
Stronger Together!
0465
Protein Modification by Cope Rearrangement
0466
Potent and Selective Acid Sphingomyelinase Inhibitors with Antidepressant Activity
0467
Replacing HN3 with Nitromethane for Schmidt-Type Formation of Amides and Nitriles
0468
Lasonolide A is a Prodrug Activated by LDAH, a Serine Hydrolase
0469
PEP-K: A New Reagent for the O-Phosphorylation of Alcohols
0470
Modular, Targeted IDO Inhibitor for Cancer Immunotherapy
0471
A Potential anti-Pertussis Vaccine Based on Lipopolysaccharide Endotoxins of B. pertussis
0472
A Carbapenemase Probe that Switches on the Light
0473
Cyclic Naphthoquinone Imine Based Antagonists of the RIG-I Innate Immune Receptor
0474
Optical Control of CENP-E Function
0475
A Classic Way of Forming Amide Bonds

Peptide Chemistry

z0477
All PDFs of this category
0477
Boronic Acid Catalyzed Dehydrative Peptide Synthesis
0478
Phase-Transfer-Catalyzed Enantioselective α-Trifluoromethylthiolation
0479
Stereoselective Synthesis of β-Amino Acid Precursors by Organocatalysis
0480
Copper-Catalyzed [3+1] Cycloaddition to Form Substrates for α-Amino Acid Synthesis
0481
Synthesis of Selenocystine-based Peptides through Cyclization Reactions
0482
Copper-Catalyzed Synthesis of Cyanated Peptides
0483
Stereoselective Synthesis of Unnatural α-Amino Acids
0484
Palladium-Catalyzed N-Arylation of Amino Acids and Ketoxime Peptide Ligation
0485
Synthesis of α-Quaternary Chiral Amino Acids by Palladium-Catalyzed Arylation
0486
Synthesis of Fmoc-Aminoacyl‑N‑alkylcysteine Dipeptides by Using the Ugi Reaction
0487
Solid-State Synthesis of a β-Turn Mimetic

Flow Chemistry

z0489
All PDFs of this category
0489
Synthesis of Biaryl Compounds in Flow via a Lithiation, Borylation, Suzuki–Miyaura Cross-Coupling Pathway
0490
Ferrocenyl Azide Synthesis via Halogen–Lithium Exchange in Continuous Flow
0491
Acylation with Grignard Reagents in Continuous Flow