DOI: 10.1055/s-00035024

Thrombosis and Haemostasis

Issue 07 · Volume 70 · 1993 DOI: 10.1055/s-009-45152

Plenary Lecture

001
Roberts, Harold R: Molecular Biology of Hemophilia B
010
Rosenberg, Robert D: Vascular Smooth Muscle Cell Proliferation: Basic Investigations and New Therapeutic Approaches
017
Mannucci, Pier Mannuccio: Modern Treatment of Hemophilia: From the Shadows Towards the Light
024
Doolittle, Russell F: The Evolution of Vertebrate Blood Coagulation: A Case of Yin and Yang
029
Esmon, Charles T: Molecular Events that Control the Protein C Anticoagulant Pathway
036
Radomski, Marek W; Moncada, Salvador: Regulation of Vascular Homeostasis by Nitric Oxide
042
Henschen, Agnes H: Human Fibrinogen—Structural Variants and Functional Sites
048
Iwanaga, Sadaaki: Primitive Coagulation Systems and their Message to Modern Biology

State-of-the-Art Lecture

Hemophilia

056
Nilsson, Inga Marie; Berntorp, Erik; Freiburghaus, Christian: Treatment of Patients with Factor VIII and IX Inhibitors
060
Kazazian, Haig H: The Molecular Basis of Hemophilia A and the Present Status of Carrier and Antenatal Diagnosis of the Disease
063
Fay, Philip J: Factor VIII Structure and Function

Factor XI

068
Seligsohn, Uri: Factor XI Deficiency
072
Broze, George J; Gailani, David: The Role of Factor XI in Coagulation
075
Walsh, Peter N; Baglia, Frank A; Jameson, Bradford A: Factor XI and Platelets: Activation and Regulation

Plateley Receptors

080
Nesheim, Michael E; Furmaniak-Kazmierczak, Emilia; Henin, Christine; Côté, Graham: On the Existence of Platelet Receptors for Factor V(a) and Factor VIII(a)
087
Ginsberg, Mark H; Xiaoping, Du; O'Toole, Timothy E; Loftus, Joseph C; Plow, Edward F: Platelet Integrins
094
Topol, Eric J; Plow, Edward F: Clinical Trials of Platelet Receptor Inhibitors

von Willebrand Factor

099
Meyer, Dominique; Girma, Jean-Pierre: von Willebrand Factor: Structure and Function
105
Wagner, Denisa D: The Weibel-Palade Body: the Storage Granule for von Willebrand Factor and P-selectin
111
Badimon, Lina; Badimon, Juan J; Chesebro, James H; Fuster, Valentin: von Willebrand Factor and Cardiovascular Disease

Flow

119
Ruggeri, Zaverio M: Mechanisms of Shear-induced Platelet Adhesion and Aggregation
124
Davies, Peter F: Endothelium as a Signal Transduction Interface for Flow Forces: Cell Surface Dynamics
129
Slack, Steven M; Cui, Yingwen; Turitto, Vincent T: The Effects of Flow on Blood Coagulation and Thrombosis

Plasminogen Activator Inhibitors

135
Loskutoff, David J; Sawdey, Michael; Keeton, Mark; Schneiderman, Jacob: Regulation of PAI-1 Gene Expression In Vivo
138
Juhan-Vague, Irène; Alessi, Marie Christine: Plasminogen Activator Inhibitor 1 and Atherothrombosis
144
Belin, Dominique: Biology and Facultative Secretion of Plasminogen Activator Inhibitor-2

Vascular Wall Biology

148
Ignarro, Louis J: Nitric Oxide-mediated Vasorelaxation
155
Ward, Peter A; Mulligan, Michael S; Vaporciyan, Ara A: Endothelial and Leukocytic Adhesion Molecules in the Pathogenesis of Acute Pulmonary Injury

State-of-the-Art Lectures

Vascular Wall Biology

152
Bevilacqua, Michael P; Nelson, Richard M: Endothelial-Leukocyte Adhesion Molecules in Inflammation and Metastasis

State-of-the-Art Lecture

Thrombin

158
Stiernberg, Janet; Redin, William R; Scott Warner, W; Carney, Darrell H: The Role of Thrombin and Thrombin Receptor Activating Peptide (TRAP-508) in Initiation of Tissue Repair
163
Van Obberghen-Schilling, Ellen; Pouysségur, Jacques: Signaling Pathways of the Thrombin Receptor
168
Cunningham, Dennis D; Pulliam, Lynn; Vaughan, Patrick J: Protease Nexin-1 and Thrombin: Injury-related Processes in the Brain

Growth Factors

172
Reidy, Michael A: Neointimal Proliferation: The Role of Basic FGF on Vascular Smooth Muscle Cell Proliferation
177
Rifkin, Daniel B; Kojima, Soichi; Abe, Mayumi; Harpel, John G: TGF-β: Structure, Function, and Formation
180
Taubman, Mark B: Gene Induction in Vessel Wall Injury

Vessel Wall Receptors

184
Coughlin, Shaun R: Thrombin Receptor Structure and Function
188
Griendling, Kathy K; Lassègue, Bernard; Wayne Alexander, R: The Vascular Angiotensin (AT1) Receptor

Gene Therapy

193
Kurachi, Kotoku; Yao, Shou-Nan: Gene Therapy of Hemophilia B
198
Dichek, David A: Gene Transfer in the Treatment of Thrombosis
202
Nabel, Elizabeth G; Nabel, Gary J: Direct Gene Transfer: Basic Studies and Human Therapies

Anticoagulation

204
Hirsh, Jack: Low Molecular Weight Heparin
208
Maraganore, John M: Thrombin, Thrombin Inhibitors, and the Arterial Thrombotic Process
212
Vlasuk, George P: Structural and Functional Characterization of Tick Anticoagulant Peptide (TAP): A Potent and Selective Inhibitor of Blood Coagulation Factor Xa

Platelet Signaling

217
Brass, Lawrence F; Hoxie, James A; Manning, David R: Signaling through G Proteins and G Protein-coupled Receptors during Platelet Activation
224
Shattil, Sanford J: Regulation of Platelet Anchorage and Signaling by Integrin αIIbβ3
229
Furman, Mark I; Gardner, Timothy M; Goldschmidt-Clermont, Pascal J: Mechanisms of Cytoskeletal Reorganization during Platelet Activation