Download PDF
Thromb Haemost 1993; 70(01): 163-167
DOI: 10.1055/s-0038-1646181
State-of-the-Art Lecture
Thrombin
Schattauer GmbH Stuttgart

Signaling Pathways of the Thrombin Receptor

Ellen Van Obberghen-Schilling
Centre Biochimie CNRS-INSERM, Nice, FRANCE
,
Jacques Pouysségur
Centre Biochimie CNRS-INSERM, Nice, FRANCE
› Author Affiliations
Further Information

Publication History

Publication Date:
03 July 2018 (online)

  PDF Download  Permissions and Reprints
 

  • References

  • 1 Barnard EA. Receptor classes and the transmitter-gated ion channels. Trends Biochem Sci 1992; 17: 368-374
    CrossrefPubMedGoogle Scholar
  • 2 Vu TKH, Hung D, Wheaton VI, Coughlin SR. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 1991; 64: 1057-1068
    CrossrefPubMedGoogle Scholar
  • 3 Rasmussen UB, Vouret-Craviari V, Jallat S, Schlesinger Y, Pagès G, Pavirani A, Lecocq JP, Pouysségur J, Van Obberghen-Schilling E. cDNA cloning and expression of a hamster α-thrombin receptor coupled to Ca2+ mobilization. FEBS Lett 1991; 288: 123-128
    CrossrefPubMedGoogle Scholar
  • 4 Zhong C, Hayzer DJ, Corson MA, Runge MS. Molecular cloning of the rat vascular smooth muscle thrombin receptor. J Biol Chem 1992; 267: 16975-16979
    PubMedGoogle Scholar
  • 5 Nathans J. Rhodopsin: Structure, function and genetics. Biochemistry 1992; 31: 4923-4930
    CrossrefPubMedGoogle Scholar
  • 6 Savarese TM, Fraser CM. In vitro mutagenesis and the search for structure-function relationships among G protein-coupled receptors. Biochem J 1992; 283: 1-19
    CrossrefPubMedGoogle Scholar
  • 7 Bode W, Schwager P, Huber R. The transition of bovine trypsinogen to a trypsin-like state upon strong ligand binding. J Mol Biol 1978; 118: 99-112
    CrossrefPubMedGoogle Scholar
  • 8 Vouret-Craviari V, Van Obberghen-Schilling E, Rasmussen UB, Pavirani A, Lecocq JP, Pouysségur J. Synthetic α-thrombin receptor peptides activate G protein-coupled signaling pathways but are unable to induce mitogenesis. Mol Biol Cell 1992; 3: 95-102
    CrossrefPubMedGoogle Scholar
  • 9 Vassallo RR, Kieber-Emmons T, Cichowski K, Brass LF. Structure-function relationships in the activation of platelet thrombin receptors by receptor-derived peptides. J Biol Chem 1992; 267: 6081-6085
    PubMedGoogle Scholar
  • 10 Scarborough RM, Naughton MA, Teng W, Huang DT, Rose J, Vu T-KH, Wheaton VI, Turck CW, Coughlin SR. Tethered ligand agonist peptides. J Biol Chem 1992; 287: 13146-13149
    PubMedGoogle Scholar
  • 11 Chao BH, Kalkunte S, Maraganore JM, Stone SR. Essential groups in synthetic agonist peptides for activation of the platelet thrombin receptor. Biochemistry 1992; 31: 6175-6178
    CrossrefPubMedGoogle Scholar
  • 12 Van Obberghen-Schilling E, Rasmussen UB, Vouret-Craviari V, Lentes KU, Pavirani A, Pouysségur J. Structure-activity analysis of synthetic α-thrombin receptor activating peptides. Biochem J. 1993 in press
    PubMedGoogle Scholar
  • 13 L'Allemain G, Paris S, Magnaldo I, Pouysségur J. a-thrombin-induced inositol phosphate formation in GO-arrested and cycling hamster lung fibroblasts: evidence for a protein kinase C-mediated desensitization response. J Cell Physiol 1986; 129: 167-174
    CrossrefPubMedGoogle Scholar
  • 14 Magnaldo I, Pouysségur J, Paris S. Thrombin exerts a dual effect on stimulated adenylate cyclase in hamster fibroblasts: an inhibition via a GTP-binding protein and a potentiation via activation of protein kinase C. Biochem J 1988; 253: 711-719
    CrossrefPubMedGoogle Scholar
  • 15 McKenzie FR, Seuwen K, Pouysségur J. Stimulation of phosphatidylcholine breakdown by thrombin and carbachol but not by tyrosine kinase receptor ligands in cells transfected with Ml muscarinic receptors. J Biol Chem 1992; 267: 22759-22769
    PubMedGoogle Scholar
  • 16 Brass LW, Woolkalis MJ. Dual regulation of cyclic AMP formation by thrombin in HEL cells, a leukaemic cell line with megakaryocytic properties. Biochem J 1992; 281: 73-80
    CrossrefPubMedGoogle Scholar
  • 17 Paris S, Pouysségur J. Pertussis toxin inhibits thrombin-induced activation of phosphoinositide hydrolysis and Na+/H+ exchange in hamster fibroblasts. EMBO J 1986; 5: 55-60
    PubMedGoogle Scholar
  • 18 Chambard JC, Paris S, L'Allemain G, Pouysségur J. Two growth factor signalling pathways in fibroblasts distinguished by pertussis toxin. Nature 1987; 326: 800-803
    CrossrefPubMedGoogle Scholar
  • 19 Brass LF, Laposata F, Banga HS, Rittenhouse SE. Regulation of the phosphoinositide hydrolysis pathway in thrombin-stimulated platelets by a pertussis toxin-sensitive guanine nucleotide-binding protein. J Biol Chem 1986; 261: 16833-16847
    PubMedGoogle Scholar
  • 20 Huang CL, Ives HE. Guanosine 5'-O-(3-thiotrisphosphate) potentiates both thrombin- and platelet-derived growth factor-induced inositol phosphate release in permeabilized vascular smooth muscle cells. J Biol Chem 1989; 264: 4391-4397
    PubMedGoogle Scholar
  • 21 Brock TA, Capasso EL. GTPγS increases thrombin-mediated inositol trisphosphate accumulation in permeabilized human endothelial cells. Am Rev Respir Dis 1989; 140: 1121-1125
    CrossrefPubMedGoogle Scholar
  • 22 Garcia JGN, Painter RG, Fenton JWI, English D, Callahan KS. Thrombin-induced prostacyclin biosynthesis in human endothelium: role of guanine nucleotide regulatory proteins in stimulus/coupling responses. J Cell Physiol 1990; 142: 186-193
    CrossrefPubMedGoogle Scholar
  • 23 Helper J, Gilman AG. G proteins. Trends Biochem Sci 1992; 17: 383-387
    CrossrefPubMedGoogle Scholar
  • 24 Wu D, Lee C-H, Rhee SG, Simon MI. Activation of phospholipase C by the α subunits of the Gq and G11 proteins in transfected Cos-7 cells. J Biol Chem 1992; 267: 1811-1817
    PubMedGoogle Scholar
  • 25 Wu D, Katz A, Lee CH, Simon MI. Activation of phospholipase C by α1-adrenergic receptors is mediated by the a subunits of the Gq family. J Biol Chem 1992; 267: 25798-25802
    PubMedGoogle Scholar
  • 26 Hung DT, Wong YH, Vu TKH, Coughlin SR. The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase. J Biol Chem 1992; 267: 20831-20834
    PubMedGoogle Scholar
  • 27 Birnbaumer L. Receptor-to-effector signaling through G proteins: roles for βγ dimers as well as α subunits. Cell 1992; 71: 1069-1072
    CrossrefPubMedGoogle Scholar
  • 28 Paris S, Chambard JC, Pouysségur J. Tyrosine kinase-activating growth factors potentiate thrombin- and A1F- 4 -induced phosphoinositide breakdown in hamster fibroblasts: evidence for positive cross-talk between the two mitogenic signaling pathways. J Biol Chem 1988; 263: 12893-12900
    PubMedGoogle Scholar
  • 29 Méloche S, Seuwen K, Pagès G, Cobb MH, Pouysségur J. Biphasic and synergistic activation of p44mapk (ERK1) by growth factors: Correlation between late phase activation and mitogenicity. Mol Endocrinol 1992; 6: 845-854
    PubMedGoogle Scholar
  • 30 Vouret-Craviari V, Van Obberghen-Schilling E, Scimeca JC, Van Obberghen E, Pouysségur J. Differential activation of p44 mapk (ERK1) by α-thrombin and synthetic receptor peptide agonists. Biochem J 1993; 289: 209-214
    CrossrefPubMedGoogle Scholar
  • 31 Seuwen K, Kahan C, Hartmann T, Pouysségur J. Strong and persistent activation of inositol lipid breakdown induces early mitogenic events but not Go to S phase progression in hamster fibroblasts. J Biol Chem 1990; 265: 22292-22299
    PubMedGoogle Scholar
  • 32 Seuwen K, Magnaldo I, Kobilka BK, Caron MG, Regan JW, Lefkowitz RJ, Pouysségur J. α2-Adrenergic agonists stimulate DNA synthesis in Chinese hamster lung fibroblasts transfected with a human α2-adrenergic receptor gene. Cell Regul 1990; 1: 445-451
    CrossrefPubMedGoogle Scholar
  • 33 Van Obberghen-Schilling E, Vouret-Craviari V, Haslam RJ, Chambard JC, Pouysségur J. Cloning, functional expression and role in cell growth regulation of a hamster 5-HT2 receptor subtype. Mol Endocrinol 1991; 5: 881-889
    CrossrefPubMedGoogle Scholar
  • 34 Pouysségur J, Chambard JC, Franchi A, L'Allemain G, Paris S. Van Obberghen-Schilling E. Growth factor activation of the Na+/H+ antiporter controls growth of fibroblasts by regulating intracellular pH. In: Cancer Cells. Feramisco J, Ozanne B, Stiles C. (eds). Cold Spring Harbor Laboratory, Cold Spring Harbor; New York: 1985. pp. 409-415
    Google Scholar
  • 35 Sardet C, Counillon L, Franchi A, Pouysségur J. Growth factors induce phosphorylation of the Na+/H+ antiporter, a glycoprotein of 110kD. Science 1990; 247: 723-726
    CrossrefPubMedGoogle Scholar
  • 36 Livne AA, Sardet C, Pouysségur J. The Na+/H+ exchanger is phosphorylated in human platelets in response to activating agents. FEBS Lett 1991; 284: 219-222
    CrossrefPubMedGoogle Scholar
  • 37 Cobb M, Robbins DJ, Boulton TG. ERK's, extracellular signal-regulated MAP-2 kinases. Current Opin Cell Biol 1992; 3: 1025-1032
    PubMedGoogle Scholar
  • 38 Lenormand P, Pagès G, Sardet C, L'Allemain G, Méloche S, Pouysségur J. MAP kinases: activation, subcellular localization and role in the control of cell proliferation. In: (Advances in Second Messenger and Phosphoprotein Research; Vol. 28). Markovac J. (ed). Raven Press; New York: 1993. pp. 237-244
    Google Scholar
  • 39 Chen R-H, Sarnecki C, Blenis J. Nuclear localization and regulation of erk- and rsk-encoded protein kinases. Mol Cell Biol 1992; 12: 915-927
    CrossrefPubMedGoogle Scholar
  • 40 Crews CM, Alessandrini A, Erikson RL. The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product. Science 1992; 258: 478-480
    CrossrefPubMedGoogle Scholar
  • 41 Ashworth A, Nakielny S, Cohen P, Marshall C. The amino acid sequence of a mammalian MAP kinase kinase. Oncogene 1992; 7: 2555-2556
    PubMedGoogle Scholar
  • 42 Kyriakis JM, App H, Zhan X, Banerjee P, Brautigan DL, Rapp UR, Avruch J. Raf-1 activates MAP kinase-kinase. Nature 1992; 358: 417-421
    CrossrefPubMedGoogle Scholar
  • 43 Dent P, Haser W, Haystead TAJ, Vincent LA, Roberts TM, Sturgill TW. Activation of mitogen-activated protein kinase kinase by v-raf in NIH 3T3 cells and in vitro. Nature 1992; 257: 1404-1407
    PubMedGoogle Scholar
  • 44 Lin L-L, Wartmann M, Lin AY, Knopf JL, Seth A, Davis RJ. cPLA2 is phosphorylated and activated by MAP kinase. Cell 1993; 72: 269-278
    CrossrefPubMedGoogle Scholar
  • 45 Susa M, Olivier AR, Fabbro D, Thomas G. EGF induces biphasic S6 kinase activation: late phase is protein kinase C-dependent and contributes to mitogenicity. Cell 1989; 57: 817-824
    CrossrefPubMedGoogle Scholar
  • 46 Kahan C, Seuwen K, Meloche S, Pouysségur J. Coordinate, biphasic activation of p44 mitogen-activated protein kinase and S6 kinase by growth factors in hamster fibroblasts. J Biol Chem 1992; 267: 13369-13375
    PubMedGoogle Scholar
  • 47 Ferrell Jr. JE, Martin GS. Platelet tyrosine-specific protein phosphorylation is regulated by thrombin. Mol Cell Biol 1988; 8: 3603-3610
    CrossrefPubMedGoogle Scholar
  • 48 Golden A, Brugge JS. Thrombin treatment induces rapid changes in tyrosine phosphorylation in platelets. Proc Natl Acad Sci USA 1989; 86: 901-905
    CrossrefPubMedGoogle Scholar
  • 49 Lipfert L, Haimovich B, Schallar MD, Cobb BS, Parsons JT, Brugge JS. Integrin-dependent phosphorylation and activation of the protein tyrosine kinase ppl25FAK in platelets. J Cell Biol 1992; 119: 905-912
    CrossrefPubMedGoogle Scholar
  • 50 Shaller MD, Borgman CA, Cobb BS, Vines RR, Reynolds AB, Parsons JT. ppl25FAK, a structurally distinctive protein-tyrosine kinase associated with focal adhesions. Proc Natl Acad Sci USA 1992; 89: 5192-5196
    CrossrefPubMedGoogle Scholar
  • 51 Van Obberghen-Schilling E, Chambard JC, Paris S, L'Allemain G, Pouysségur J. α-Thrombin-induced early mitogenic signalling events and GO to S-phase transition of fibroblasts require continual external stimulation. EMBO J 1985; 4: 2927-2932
    PubMedGoogle Scholar
  • 52 Hunter T, Karin M. The regulation of transcription by phosphorylation. Cell 1992; 70: 375-387
    CrossrefPubMedGoogle Scholar
  • 53 Daniel TO, Gibbs VC, Milfay DF, Garavoy MR, Williams LT. Thrombin stimulates c-sis gene expression in microvascular endothelial cells. J Biol Chem 1986; 261: 9579-9582
    PubMedGoogle Scholar
  • 54 Weiss RH, Ives HE. Dissociation between activation of growth-related genes and mitogenic responses of neonatal vascular smooth muscle cells. Biochem Biophys Res Comm 1991; 181: 617-622
    CrossrefPubMedGoogle Scholar