DOI: 10.1055/s-00035024

Thrombosis and Haemostasis

Ausgabe 11 · Volume 102 · 2009 DOI: 10.1055/s-008-36065

Editorial Focus

799
Hayward, Catherine P. M.: Advances in Understanding “High on-Treatment Platelet Reactivity”

Theme Issue Editorial

801
Harenberg, Job; Casu, Benito: Heparin and its derivatives - Present and future

Theme Issue Article

804
Petitou, Maurice; Nancy-Portebois, Vanessa; Dubreucq, Guy; Motte, Vincent; Meuleman, Dick; de Kort, Martin; van Boeckel, Constant A. A.; Vogel, Gerard M. T.; Wisse, Jeffry A. J.: From heparin to EP217609: The long way to a new pentasaccharide-based neutralisable anticoagulant with an unprecedented pharmacological profile
811
Harenberg, Job: Development of idraparinux and idrabiotaparinux for anticoagulant therapy
816
Schlesinger, Martin; Simonis, Dirk; Schmitz, Patrick; Fritzsche, Juliane; Bendas, Gerd: Binding between heparin and the integrin VLA-4
823
Li, Jin-ping; Vlodavsky, Israel: Heparin, heparan sulfate and heparanase in inflammatory reactions
829
Fonseca, Roberto J. C.; Santos, Gustavo R. C.; Mourão, Paulo A. S.: Effects of polysaccharides enriched in 2,4-disulfated fucose units on coagulation, thrombosis and bleeding
837
Collino, Massimo; Castiglia, Sara; Manoni, Marco; Salsini, Liana; Chini, Jacopo; Masini, Emanuela; Fantozzi, Roberto: Effects of a semi-synthetic N-,O-sulfated glycosaminoglycan K5 polysaccharide derivative in a rat model of cerebral ischaemia/ reperfusion injury
846
Liverani, Lino; Mascellani, Giuseppe; Spelta, Franco: Heparins: Process-related physico-chemical and compositional characteristics, fingerprints and impurities
854
Sasisekharan, Ram; Shriver, Zachary: From crisis to opportunity: A perspective on the heparin crisis
859
Szelke, Helga; Harenberg, Job; Krämer, Roland: Detection and neutralisation of heparin by a fluorescent ruthenium compound
865
Bisio, Antonella; Vecchietti, Davide; Citterio, Laura; Guerrini, Marco; Raman, Rahul; Bertini, Sabrina; Eisele, Giorgio; Naggi, Annamaria; Sasisekharan, Ram; Torri, Giangiacomo: Structural features of low-molecular-weight heparins affecting their affinity to antithrombin
874
Rudd, Timothy R.; Skidmore, Mark A.; Guimond, Scott E.; Holman, Joseph; Turnbull, Jeremy E.; Lauder, Robert M.; Fernig, David G.; Yates, Edwin A.: The potential for circular dichroism as an additional facile and sensitive method of monitoring low-molecular-weight heparins and heparinoids
879
Vardi, Moshe; Laor, Arie; Bitterman, Haim: Activated partial thromboplastin time monitoring in patients receiving unfractionated heparin for venous thromboembolism in relation to clinical outcomes
887
Nowak, Götz: Heparin-induced thrombocytopenia (HIT II) – A drug-associated autoimmune disease
892
Laux, Volker; Perzborn, Elisabeth; Heitmeier, Stefan; von Degenfeld, Georges; Dittrich-Wengenroth, Elke; Buchmüller, Anja; Gerdes, Christoph; Misselwitz, Frank: Direct inhibitors of coagulation proteins – the end of the heparin and low-molecular-weight heparin era for anticoagulant therapy?
900
Kishimoto, Takashi Kei; Qi, Yi Wei; Long, Alison; Capila, Ishan; Sasisekharan, Ram; Guerrero, Luis; Fier, Ian; Roach, James; Venkataraman, Ganesh: M118 – A rationally engineered low-molecular-weight heparin designed specifically for the treatment of acute coronary syndromes

Issue Article

907
Guerrini, Marco; Shriver, Zachary; Bisio, Antonella; Naggi, Annamaria; Casu, Benito; Sasisekharan, Ram; Torri, Giangiacomo: The Tainted Heparin Story: An Update

Pro/Contra Article

912
Healey, Jeff S.: Pro: “Anti-platelet therapy is an alternative to oral anticoagulation for atrial fibrillation”
914
Apostolakis, Stavros; Shantsila, Eduard; Lip, Gregory Y. H.; Lane, Deirdre A.: Contra: “Anti-platelet therapy is an alternative to oral anticoagulation for atrial fibrillation”

Review Article

916
Shantsila, Eduard; Lip, Gregory Y. H.: The role of monocytes in thrombotic disorders

Blood Coagulation, Fibrinolysis and Cellular Haemostasis

925
Heinz, Stefan; Schüttrumpf, Jörg; Simpson, Jeremy C.; Pepperkok, Rainer; Nicolaes, Gerry A.; Abriss, Daniela; Milanov, Peter; Roth, Stefanie; Seifried, Erhard; Tonn, Torsten: Factor VIII-eGFP fusion proteins with preserved functional activity for the analysis of the early secretory pathway of factor VIII
936
Machlus, Kellie R.; Colby, Emily A.; Wu, Jogin R.; Koch, Gary G.; Key, Nigel S.; Wolberg, Alisa S.: Effects of tissue factor, thrombomodulin and elevated clotting factor levels on thrombin generation in the calibrated automated thrombogram
945
Agledahl, Ingvild; Brodin, Ellen; Svartberg, Johan; Hansen, John-Bjarne: Impact of long-term testosterone treatment on plasma levels of free TFPI and TF-induced thrombin generation ex vivo in elderly men with low testosterone levels
951
Spyropoulos, Alex C.; Hussein, Mohamed; Lin, Jay; Battleman, David: Rates of venous thromboembolism occurrence in medical patients among the insured population

Platelets and Blood Cells

958
Eshel-Green, Tal; Berny, Michelle A.; Conley, Robert B.; McCarty, Owen J. T.: Effect of sex difference on platelet adhesion, spreading and aggregate formation under flow
966
Brouckova, Adela; Holada, Karel: Cellular prion protein in blood platelets associates with both lipid rafts and the cytoskeleton

Endothelium and Vascular Development

975
Dardik, Rima; Livnat, Tami; Seligsohn, Uri: Variable effects of alpha v suppression on VEGFR-2 expression in endothelial cells of different vascular beds

Cardiovascular Biology and Cell Signalling

983
Massey, Philip G.; Tanaka, Shinji; Buckler, Joshua M.; Jiang, Bo; McCourtie, Anton; Qian, Kun; Tom, Clifford; Stempien-Otero, April; Wen, Shan; Luttrell, Ian; Chitaley, Kanchan; Dichek, David A.: Constriction of carotid arteries by urokinase-type plasminogen activator requires catalytic activity and is independent of NH2-terminal domains
Zusatzmaterial

Animal Models

993
Cleuren, Audrey C. A.; van Hoef, Berthe; Hoylaerts, Marc F.; van Vlijmen, Bart J. M.; Lijnen, H. Roger: Short-term ethinylestradiol treatment suppresses inferior caval vein thrombosis in obese mice

New Technologies, Diagnostic Tools and Drugs

1001
Dempfle, Carl-Erik; Zharkowa, Ulyana; Elmas, Elif; Ahmad-Nejad, Parviz; Neumaier, Michael; Borggrefe, Martin: Heptest-STAT, a new assay for monitoring of low-molecular-weight heparins, is not influenced by pregnancy-related changes of blood plasma