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DOI : 10.1055/s-00000034

Klinische Pädiatrie

Issue 03 · Volume 228 · May 2016 DOI: 10.1055/s-006-31605

29. Jahrestagung der Kind-Philipp-Stiftung für pädiatrisch-onkologische Forschung
Wilsede, Lüneburger Heide, 1.6. – 3. 6. 2016

Wissenschaftliche Leitung: Prof. Dr. Martin Horstmann – Prof. Dr. Martin Stanulla – Prof. Dr. Rolf Marschalek – Prof. Dr. Olaf Heidenreich

Abstracts (HTML) List of Authors

Top 1: Acute and chronic leukaemias

Moll, N; Demir, S; Selivanova, G; Debatin, KM; Meyer, LH: Targeting p53-MDM 2 interaction in pediatric ALL

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Stächele, J; Töpfner, N; Herold, C; Berner, R; Bornhäuser, M; Guck, J; Suttorp, M: Mechanical phenotyping of leukemic blast cells using real-time deformability cytometry

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Hinze, L; Möricke, A; Cario, G; Zimmermann, M; Conter, V; Schrappe, M; Stanulla, M: Prognostic impact of IKZF1 deletions in association with vincristine-dexamethasone pulses during maintenance treatment of childhood acute lymphoblastic leukemia on trial AIEOP-BFM ALL 95

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Sun, Q; Debatin, KM; Meyer, LH: Effective targeting of Acute Lymphoblastic Leukemia (ALL) by CD70 directed immunotherapy

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Mahnken, A; Klusmann, JH: Comparison of different tag purification approaches to create GATA1-/GATA1 s-centered protein interaction networks

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Matthes, LA; Reimer, J; Knoess, S; Klusmann, JH; Heckl, D: Nup98-Kdm5a, induced via CRISPR-Cas9 genome editing, transforms murine hematopoietic stem cells

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Flasinski, M; Emmrich, S; Alejo, O; Keihani, S; Klusmann, JH: Cooperation between members of the miR-99/100˜125 cluster and PML-RARα in leukemic transformation

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Ng, M; Santer, L; Emmrich, S; Schwarzer, A; Reinhardt, D; Klusmann, JH: CRISPRi/a screening to identify functional long non-coding RNAs in pediatric acute myeloid leukemia

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Alejo, O; Emmrich, S; Flasinski, M; Keihani, S; Klusmann, JH: Members of the miR-99/100˜125 tricistrons cooperatively induce a pre-leukemic phenotype

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A10

Al-Kershi, S; Emmrich, S; Reimer, C; Klusmann, JH: Stem cell-enriched long non-coding RNA HOXA-AS4 contributes to the pathogenesis of MLL-rearranged AML

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A11

Elder, AK; Heidenreich, O; Vormoor, HJ: Spatial diversity of abundant and equipotent founder clones in acute lymphoblastic leukaemia

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A12

Sundaresh, A; Gasparoli, L; Mangolini, M; Edwards, D; Hubank, M; Brooks, T; Bartram, J; Goulden, N; Ancliff, P; de Boer, J; Williams, O: Aberrant transcriptional pathways in t(12;21) Acute Lymphoblastic Leukemia

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A13

Marencke, N; Schmäh, J; Zimmermann, M; Schewe, D; Moericke, A; Alten, J; Bleckmann, K; Schrappe, M; Stanulla, M; Cario, G: Impact of the gene expression of natural killer cell receptors and their ligands for treatment response and prognosis in pediatric acute lymphoblastic leukemia

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A14

Cantilena, S; Heidenreich, O; Klussman, JH; Williams, O; de Boer, J: Redeployed drug inducing MLL fusion degradation

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A15

Köhrer, S; Seyfried, F; Debatin, KM; Müschen, M; Meyer, LH; Davis, RE; Burger, JA: Pre-BCR expression predicts sensitivity to SYK inhibition in B-cell acute lymphoblastic leukemia

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A16

Junk, S; Klein, N; Schreek, S; Zimmermann, M; Möricke, A; Bleckmann, K; Cario, G; Kratz, CP; Schrappe, M; Stanulla, M: TP53 single nucleotide variants (SNV) in patients developing second malignant neoplasms after treatment for childhood acute lymphoblastic leukemia

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A17

Martinez-Soria, N; McKenzie, L; Nakjang, S; Forster, V; Blair, HJ; Heidenreich, O: t(8;21) Acute Myeloid Leukaemia Requires Active CCND-CDK4/6

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A18

Hörl, R; Seyfried, F; Demir, S; Zinngrebe, J; Köhrer, S; Debatin, KM; Meyer, LH: Efficacy of the BH3-mimetic ABT-199 in acute lymphoblastic leukemia

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A19

Shi, Y; Heidenreich, O; van Delft, F; Krippner-Heidenreich, A: Investigation of the role of pre T Cell Receptor signalling in T-cell Acute Lymphoblastic Leukaemia

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A20

Weiland, J; Pal, D; Case, M; Irving, J; Ponthan, F; Koschmieder, S; Heidenreich, O; Stackelberg, A von; Eckert, C; Vormoor, J; Elder, A: BCP-ALL blasts are not dependent on CD19 expression for leukaemic maintenance

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A21

Demir, S; Selivanova, G; Tausch, E; Wiesmüller, L; Stilgenbauer, S; te Kronnie, G; Debatin, KM; Meyer, LH: Targeting mutant TP53 in ALL

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A22

Krombholz, CF; Fluhr, S; Niemeyer, CM; Flotho, C; Erlacher, M: Antileukemic activity of the azacitidine in a xenograft model of juvenile myelomonocytic leukemia

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