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Methods Inf Med 2009; 48(01): 18-28
DOI: 10.3414/ME9133
Original Articles
Schattauer GmbH

Signal Informatics as an Advanced Integrative Concept in the Framework of Medical Informatics

New Trends Demonstrated by Examples Derived from Neuroscience

Authors

  • H. Witte

    1   Institute of Medical Statistics, Computer Sciences and Documentation, Bernstein Group Computational Neuroscience, Friedrich Schiller University, Jena, Germany

  • M. Ungureanu

    1   Institute of Medical Statistics, Computer Sciences and Documentation, Bernstein Group Computational Neuroscience, Friedrich Schiller University, Jena, Germany

  • C. Ligges

    2   Department of Child and Adolescent Psychiatry, Friedrich Schiller University, Jena, Germany

  • D. Hemmelmann

    1   Institute of Medical Statistics, Computer Sciences and Documentation, Bernstein Group Computational Neuroscience, Friedrich Schiller University, Jena, Germany

  • T. Wüstenberg

    3   Department of Medical Psychology, Georg-August University, Göttingen, Germany

  • J. Reichenbach

    4   Institute of Diagnostic and Interventional Radiology, Friedrich Schiller University, Jena, Germany

  • L. Astolfi

    5   Department of Human Physiology and Pharmacology, University Sapienza, Rome, Italy
    6   IRCCS Fondazione S. Lucia, Rome, Italy

  • F. Babiloni

    5   Department of Human Physiology and Pharmacology, University Sapienza, Rome, Italy
    6   IRCCS Fondazione S. Lucia, Rome, Italy

  • L. Leistritz

    1   Institute of Medical Statistics, Computer Sciences and Documentation, Bernstein Group Computational Neuroscience, Friedrich Schiller University, Jena, Germany
Further Information

Publication History

Publication Date:
17 January 2018 (online)

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Summary

Objectives: The main objective is to show current topics and future trends in the field of medical signal processing which are derived from current research concepts. Signal processing as an integrative concept within the scope of medical informatics is demonstrated.

Methods: For all examples time-variant multivariate autoregressive models were used. Based on this modeling, the concept of Granger causality in terms of the time-variant Granger causality index and the time-variant partial directed coherence was realized to investigate directed information transfer between different brain regions.

Results: Signal informatics encompasses several diverse domains including: processing steps, methodologies, levels and subject fields, and applications. Five trends can be recognized and in order to illustrate these trends, three analysis strategies derived from current neuroscientific studies are presented. These examples comprise high-dimensional fMRI and EEG data. In the first example, the quantification of time-variant-directed information transfer between activated brain regions on the basis of fast-fMRI data is introduced and discussed. The second example deals with the investigation of differences in word processing between dyslexic and normal reading children. Different dynamic neural networks of the directed information transfer are identified on the basis of event-related potentials. The third example shows time-variant cortical connectivity networks derived from a source model.

Conclusions: These examples strongly emphasize the integrative nature of signal informatics, encompassing processing steps, methodologies, levels and subject fields, and applications.

Keywords

Time-variant signal analysis - model-related analysis - multivariate approach - high-dimensional and multimodal data