Cutaneous alternariosis in an immunocompromised dog successfully treated with cold plasma and cessation of immunosuppressive medication

Summary

A cutaneous infection with Alternaria spp. was diagnosed in a 2-yearold male intact Irish setter dog, presenting with multifocal papules, plaques and ulcerations involving all four distal limbs, shoulder blades, scrotum, pinnae and nasal mucous membranes. The dog had been treated for inflammatory bowel disease and lymphangiectasia with immunosuppressive doses of cyclosporine and prednisolone for approximately 3 months. The diagnosis was based on clinical signs, the demonstration of fungal elements within skin biopsies, deep fungal culture and fungal PCR from a formalin-fixed tissue specimen. Complete clinical remission was achieved by tapering and cessation of the immunosuppressive medication, treatment with cold atmospheric-pressure plasma (CAPP) and topical enilconazole within 8 weeks.

Zusammenfassung

Bei einem 2 Jahre alten, männlich intakten Irish Setter wurde eine kutane Infektion mit Alternaria spp. diagnostiziert. Der Hund zeigte Papeln, Plaques und Ulzerationen an allen distalen Gliedmaßen, Schulterblättern, Skrotum, Pinnae und nasalen Schleimhäuten. Das Tier erhielt seit ca. 3 Monaten immunsuppressive Dosen von Ciclosporin und Prednisolon zur Behandlung einer chronisch-entzündlichen Darmerkrankung und Lymphangiektasie. Die Diagnose wurde anhand der klinischen Symptomatik, dem Vorliegen von Pilzelementen in Hautbioptaten, einer Pilzkultur aus tiefen Gewebeproben sowie einer PCR-Untersuchung von formalinfixiertem Gewebe auf Pilze gestellt. Durch Absetzen der immunsuppressiven Therapie nach Dosisreduktion sowie topische Behandlung mit Kaltplasma und Enilkonazol ließ sich innerhalb von 8 Wochen eine komplette klinische Remission erreichen.

Keywords

Canine - Alternaria infection - skin - kINPen^® VET - therapy

Schlüsselwörter

Kanin - Alternaria-Infektion - Haut - kINPen^® VET - Therapie

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