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Thromb Haemost 2014; 112(05): 893-900
DOI: 10.1160/th14-03-0243
DOI: 10.1160/th14-03-0243
Theme Issue Article
Tissue factor, protease activated receptors and pathologic heart remodelling
Financial support: This work was supported by grants from the Myocarditis Foundation (S. A.) and the National Institutes of Health E. M.S (HL121990–01) and R. P. (HL096679).
Further Information
Publication History
Received:
17 March 2014
Accepted after minor revision:
30 May 2014
Publication Date:
20 November 2017 (online)
Summary
Tissue factor is the primary initiator of coagulation cascade and plays an essential role in haemostasis and thrombosis. In addition, tissue factor and coagulation proteases contribute to many cellular responses via activation of protease activated receptors. The heart is an organ with high levels of constitutive tissue factor expression. This review focuses on the role of tissue factor, coagulation proteases and protease activated receptors in heart haemostasis and the pathological heart remodelling associated with myocardial infarction, viral myocarditis and hypertension.
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References
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