Thromb Haemost 2013; 110(04): 641-650
DOI: 10.1160/TH13-03-0212
Theme Issue Article
Schattauer GmbH

More than a simple storage organ: Adipose tissue as a source of adipokines involved in cardiovascular disease

Gersina Rega-Kaun
1   Department of Internal Medicine II, Medical University Vienna, Austria
2   5th Department of Internal Medicine for Diabetes and Rheumatology, Wilhelminenhospital, Vienna, Austria
,
Christoph Kaun
1   Department of Internal Medicine II, Medical University Vienna, Austria
,
Johann Wojta
1   Department of Internal Medicine II, Medical University Vienna, Austria
3   Core Facility, Medical University of Vienna, Austria
4   Ludwig Boltzmann Cluster for Cardiovascular Research, Vienna, Austria
› Author Affiliations
Further Information

Publication History

Received: 21 March 2013

Accepted after minor revision: 19 May 2013

Publication Date:
01 December 2017 (online)

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Summary

Overweight and obesity in many countries have developed into a serious health problem by themselves and by their impact on other pathologies such as insulin resistance, type 2 diabetes, hypertension, heart disease and cancer. The modulation of these diseases by adipose tissue-derived biomolecules, so-called adipokines, could be the key to differentiate between metabolically healthy and unhealthy obesity. This review will discuss the pathophysiological role of selected adipokines, primarily focusing on cardiovascular diseases. Furthermore, we will highlight possible therapeutic approaches, which target these biomolecules.