Non-severe allergic asthma is associated with elevated plasma protein C and protein S

• References

• 1 Wildhagen KC, Lutgens E, Loubele ST. et al. The structure-function relationship of activated protein C. Lessons from natural and engineered mutations. Thromb Haemost 2011; 106: 1034-1045.
• 2 Mahmoodi BK, Brouwer JL, Ten Kate MK. et al. A prospective cohort study on the absolute risks of venous thromboembolism and predictive value of screening asymptomatic relatives of patients with hereditary deficiencies of protein S, protein C or antithrombin. J Thromb Haemost 2010; 08: 1193-1200.
• 3 Celinska-Lowenhoff M, Iwaniec T, Alhenc-Gelas M. et al. Arterial and venous thrombosis and prothrombotic fibrin clot phenotype in a Polish family with type 1 antithrombin deficiency (antithrombin Krakow). Thromb Haemost 2011; 106: 379-381.
• 4 Luxembourg B, Delev D, Geisen C. et al. Molecular basis of antithrombin deficiency. Thromb Haemost 2011; 105: 635-646.
• 5 Danese S, Vetrano S, Zhang L. et al. The protein C pathway in tissue inflammation and injury: pathogenic role and therapeutic implications. Blood 2010; 115: 1121-1130.
• 6 Shimizu S, Shimizu T, Morser J. et al. Role of the coagulation system in allergic inflammation in the upper airways. Clin Immunol 2008; 129: 365-371.
• 7 Schouten M, van de Pol MA, Levi M. et al. Early activation of coagulation after allergen challenge in patients with allergic asthma. J Thromb Haemost 2009; 07: 1592-1594.
• 8 Schouten M, vant ' Veer C, Roelofs JJ. et al. Recombinant activated protein C attenuates coagulopathy and inflammation when administered early in murine pneumococcal pneumonia. Thromb Haemost 2011; 106: 1189-1196.
• 9 De Boer JD, Van t' Veer C, Schouten M. et al. High activated protein C levels attenuate allergic lung inflammation in a murine asthma model using intranasal inoculation of house dust mite extract. J Thromb Haemost. 2011; 09 (Suppl. 02) 572 Abstract P-WE-167
• 10 Boerger LM, Morris PC, Thurnau GR. et al. Oral contraceptives and gender affect protein S status. Blood 1987; 69: 692-694.
• 11 Yuda H, Ada chi Y, Taguchi O. et al. Activated protein C inhibits bronchial hyperresponsiveness and Th2 cytokine expression in mice. Blood 2004; 103: 2196-2204.
• 12 Hataji O, Ta guchi O, Gabazza EC. et al. Activation of protein C pathway in the airways. Lung 2002; 180: 47-59.
• 13 Kanazawa H, Yoshikawa T. Up-regulation of thrombin activity induced by vascular endothelial growth factor in asthmatic airways. Chest 2007; 132: 1169-1174.
• 14 Snijders A, Van der Pouw Kraan TC, Engel M. et al. Enhanced prostaglandin E2 production by monocytes in atopic dermatitis (AD) is not accompanied by enhanced production of IL-6, IL-10 or IL-12. Clin Exp Immunol 1998; 111: 472-476.