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Thromb Haemost 2008; 99(02): 264-270
DOI: 10.1160/TH07-10-0638
Theme Issue Article
Schattauer GmbH

Glycoprotein Ibα and von Willebrand factor in primary platelet adhesion and thrombus formation: Lessons from mutant mice

Wolfgang Bergmeier
1   Cardeza Foundation for Hematologic Research and Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
,
Anil K. Chauhan
2   Immune Disease Institute
3   Department of Pathology, Harvard Medical School, Boston, Massachussetts, USA
,
Denisa D. Wagner
2   Immune Disease Institute
3   Department of Pathology, Harvard Medical School, Boston, Massachussetts, USA
› Author Affiliations Financial support: The work presented from our laboratories was supported by an American Heart Association Scientist Development Grant 0630044N (to W.B.), National Heart, Lung, and Blood Institute of the National Institutes of Health grants R37 HL41002 and P01 HL066105 (to D.D.W.), and by a Sponsored Research Agreement from Baxter, Vienna, Austria (to A.K.C. and D.D.W).
Further Information

Publication History

Received: 29 October 2007

Accepted after major revision: 11 January 2007

Publication Date:
24 November 2017 (online)

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Summary

The von Willebrand factor (VWF) receptor complex, glycoprotein (GP)Ib-V-IX, and its main ligand VWF play a key role in the adhesion process of platelets to sites of vascular injury. Recent studies in mutant mice have shed new light on the importance of either molecule for the development of arterial and venous thrombosis. In this review, we summarize the most important aspects from these studies.

Keywords

Thrombosis - glycoprotein - vonWillebrand factor - mutant - mice
 

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