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Thromb Haemost 2008; 99(04): 675-682
DOI: 10.1160/TH07-08-0526
Blood Coagulation, Fibrinolysis and Cellular Haemostasis
Schattauer GmbH

Inherited thrombophilic abnormalities and risk of portal vein thrombosis

A meta-analysis
Francesco Dentali
1   Department of Clinical Medicine, University of Insubria, Varese, Italy
,
Matteo Galli
1   Department of Clinical Medicine, University of Insubria, Varese, Italy
,
Monica Gianni
1   Department of Clinical Medicine, University of Insubria, Varese, Italy
,
Walter Ageno
1   Department of Clinical Medicine, University of Insubria, Varese, Italy
› Author Affiliations
Further Information

Publication History

Received: 29 August 2007

Accepted after major revision: 12 February 2008

Publication Date:
25 November 2017 (online)

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Summary

Inherited thrombophilic abnormalities may have a role in the development of portal vein thrombosis (PVT).However, the prevalence of these factors in patients with PVT has been evaluated only in small studies with non-conclusive results. It was the purpose of this study to assess the risk of PVT associated with factorV Leiden (FVL) and G20210A prothrombin mutation (PTM). The MEDLINE, EMBASE, Cochrane Library databases, reference lists of retrieved articles and contact with content experts were used. Studies carried out in Western Europe comparing the prevalence of prothrombotic abnormalities in patients with PVT and in controls without a history of thromboembolic disease were included. Two reviewers independently selected studies and extracted study characteristics, quality and outcomes. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for each trial and pooled using a fixed and random-effects model. Statistical heterogeneity was evaluated using the I2 statistic. Sensitivity analyses were performed examining separately studies according to the etiology of PVT and to control population. Twelve studies involving more than 3,000 patients were included. The pooled OR for PVT was 1.90 (95%CI: 1.25, 2.90) in patients with FVL and 4.48 (95%CI: 3.10, 6.48) in patients with PTM. In conclusion, PVT is associated with the presence of FVL and PTM in Western Europe.

Keywords

Thrombophilia - venous thrombosis - hepatology

 

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