Thromb Haemost 2006; 96(04): 529-534
DOI: 10.1160/TH06-05-0263
Cardiovascular Biology and Cell Signalling
Schattauer GmbH

Elevated complement C3 is associated with early restenosis after eversion carotid endarterectomy

Gábor Széplaki
1   3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
,
Lilian Varga
1   3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
,
Judit Laki
1   3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
,
Edit Doása
2   Department of Cardiovascular Surgery, Semmelweis University, Budapest, Hungary
,
Hans O. Madsen
3   Tissue-Typing Laboratory-7631, Department of Clinical Immunology, Rigshospitalet, Copenhagen, Denmark
,
Zoltán Prohászka
1   3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
4   Research Group of Metabolism and Atherosclerosis, Semmelweis University and Hungarian Academy of Sciences, Budapest, Hungary
,
Attila Szabó
2   Department of Cardiovascular Surgery, Semmelweis University, Budapest, Hungary
,
György Acsády
2   Department of Cardiovascular Surgery, Semmelweis University, Budapest, Hungary
,
László Selmeci
2   Department of Cardiovascular Surgery, Semmelweis University, Budapest, Hungary
,
Peter Garred
3   Tissue-Typing Laboratory-7631, Department of Clinical Immunology, Rigshospitalet, Copenhagen, Denmark
,
George Füst
1   3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
4   Research Group of Metabolism and Atherosclerosis, Semmelweis University and Hungarian Academy of Sciences, Budapest, Hungary
,
László Entz
2   Department of Cardiovascular Surgery, Semmelweis University, Budapest, Hungary
› Author Affiliations

Financial support: These studies were supported by the Ministry of Welfare (ETT 522/2003), the National Research Fund of Hungary (OTKA T049266, OTKA T046837) and the EC ATHERNET (QLG1-CT-2002–90397).
Further Information

Publication History

Received 14 May 2006

Accepted after resubmission 05 August 2006

Publication Date:
29 November 2017 (online)

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Summary

Early restenosis following carotid endarterectomy (CEA) is an inflammatory process leading to myointimal hyperplasia of smooth muscle cells. The risk for restenosis is increased in homozygous carriers of the normal (A) allele of mannose-binding lectin (MBL2) gene. Our objective was to study the associ-ations of C3 and as control three non-complement acute-phase reactants (APRs) (C-reactive protein, haptoglobin and α2HS-glycoprotein) with early restenosis following CEA.We also considered, whether MBL2 genotype relates to C3 levels and to the risk of restenosis. Concentrations of the APRs were determined by radial immunodiffusion or immunoturbidimetric methods in 64 patients who underwent eversion CEA and were followed up with carotid duplex scan (CDS) examinations for at least one year. MBL2 genotypes were determined by a PCR-SSP method. C3 levels increased during the follow-up and correlated with the percentage of restenosis detected by CDS at 14 months postsurgery, in MBL2 A/A allele carriers. Patients with high C3 levels had nearly five-fold higher odds for the presence of significant restenosis (>50% reduction in diameter) even after adjusting for MBL2 genotype, age and gender. By contrast, no such associations were detected between the non-complement APRs and early restenosis. C3 is associated with and might have a direct role in the development of an early restenosis following CEA, which is partially related to an intact MBL lectin pathway, thus determining C3 levels might have clinical importance. On the other hand, our results indicate that the regulation of C3 differs from non-complement APRs.