Membrane-associated CD40L and sCD40L in atherothrombotic disease

Sunil X.Anand; Juan F. Viles-Gonzalez; Juan J. Badimon; Erdal Cavusoglu; Jonathan D. Marmur

doi:10.1160/TH03-05-0268

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2003; 90(03): 377-384
DOI: 10.1160/TH03-05-0268

Review Article

Schattauer GmbH

Membrane-associated CD40L and sCD40L in atherothrombotic disease

Sunil X.Anand

¹The Zena and Michael A.Weiner Cardiovascular Institute, Mount Sinai School of Medicine, New York, New York, USA

,

Juan F. Viles-Gonzalez

¹The Zena and Michael A.Weiner Cardiovascular Institute, Mount Sinai School of Medicine, New York, New York, USA

,

Juan J. Badimon

¹The Zena and Michael A.Weiner Cardiovascular Institute, Mount Sinai School of Medicine, New York, New York, USA

,

Erdal Cavusoglu

²Department of Medicine, Division of Cardiology, SUNY Health Science Center at Brooklyn, New York, USA

,

Jonathan D. Marmur

²Department of Medicine, Division of Cardiology, SUNY Health Science Center at Brooklyn, New York, USA

› Author Affiliations

Abstract

Summary

Recent data suggests that CD40L is involved in the pathogenesis of atherothrombotic disease. This review will focus on the history of CD40L, its role in platelet-mediated pathogenesis of atherothrombotic disease, its association to clinical syndromes and procedures, and its role in determining plaque rupture.

Keywords

CD40L - atherothrombotic disease - platelets - extracellular matrix - matrix metalloproteinase

Full Text

References

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