Summary
Recent data suggests that CD40L is involved in the pathogenesis of atherothrombotic
disease. This review will focus on the history of CD40L, its role in platelet-mediated
pathogenesis of atherothrombotic disease, its association to clinical syndromes and
procedures, and its role in determining plaque rupture.
Keywords
CD40L - atherothrombotic disease - platelets - extracellular matrix - matrix metalloproteinase