Exp Clin Endocrinol Diabetes 2008; 116: S56-S58
DOI: 10.1055/s-2008-1081493
Article

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Polymorphisms in Perilipin Gene (PLIN) are not Associated with Obesity and Weight Variation in People with High Risk of Type 2 Diabetes

A. Bergmann 1 [*] , J. Li 2 [*] , M. Reimann 2 , T. Hentrich 2 , M. Hanefeld 2 , S. R. Bornstein 2 , P. E. H. Schwarz 2
  • 1Health Care Centre of Medical Faculty Carl-Gustav-Carus of the Technical University Dresden, Dresden, Germany
  • 2Department of Endocrinopathies and Metabolic Diseases, Medical Faculty Carl-Gustav-Carus of the Technical University Dresden, Dresden, Germany
Further Information

Publication History

received 13.05.2008

accepted 20.06.2008

Publication Date:
05 September 2008 (online)

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Abstract

Perilipins are hormonally regulated phosphorylated proteins that coat the intracellular lipid storage droplet [1]. They are essential for the regulation of triglyceride deposition and mobilization [2] [3]. The human perilipin gene (PLIN) is located to 15q26.1, near the susceptibility loci for obesity, and insulin-dependent diabetes mellitus, and hypertriglyceridemia. Therefore, it is considered as a candidate gene for these diseases [4]. Some studies shown that lower level of perilipin protein was displayed in obese than lean subjects [5] and polymorphisms in PLIN were associated with obesity in American and Spanish white women as well as in Korean [6] [7]. But some other studies showed that, this association was not significant in Chinese [8] and French [9]. The aim of the current study was to examine whether the associations manifested in a German population with high risk of type 2 diabetes.

References

1 These authors contributed equally to this work.

Correspondence

Dr. P. E. H. Schwarz

Medical Faculty Carl-Gustav-Carus of the Technical University Dresden

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