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Pharmacopsychiatry 2008; 41: S2-S18
DOI: 10.1055/s-2008-1081461
Original Paper

© Georg Thieme Verlag KG Stuttgart · New York

Systems Biology and Psychiatry – Modeling Molecular and Cellular Networks of Mental Disorders

F. Tretter 1 , M. Albus 2
  • 1Department of Addictions Isar Amper Clincis, Clinic Munich East, Haar/Munich, Germany
  • 2Dîrector, Isar Amper Clincis, Clinic Munich East, Haar/Munich, Germany
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Publication History

Publication Date:
28 August 2008 (online)

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Abstract

Biological psychiatry has more and more directed it's focus on the involvement of genes and molecules in mental health and disease. On these levels, new approaches in other medical fields are noticed that are collectively dubbed “Systems Biology”. Conceptually, this new paradigm tries to view molecular interactions in cellular networks as dynamic, self-organizing events that eventually result in an ordered maintenance of the whole system. A great deal of applied mathematics is required in systems biology to set up and carry out computer modeling and simulation. In terms of psychiatric research, developing “systems biology of the neuron” could become a pivotal achievement for a better understanding of mental illness on the molecular level. A brief outline of imminent tasks and links between systems biology and biological psychiatry is presented.

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Correspondence

Dr. F. Tretter

Department of Addictions Isar Amper Clincis

Clinic Munich East

85529 Haar/Munich

Germany

Phone: +49/89/4562 37 08

Fax: +49/89/4562 37 08

Email: Felix.Tretter@IAK-KMO.de

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