Planta Med 2008; 74(11): 1383-1387
DOI: 10.1055/s-2008-1081303
Pharmacology
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Inhibition of LFA-1 Mediated T-Cell Motility by Naphthoquinones

Helen Sheridan1 , Ingrid Hook1 , Cora Nestor1 , Jennifer Coppins1 , Carsten Ehrhardt1 , Neil Frankish1
  • 1Trinity College Dublin, School of Pharmacy & Pharmaceutical Sciences, Panoz Institute, Dublin, Ireland
Further Information

Publication History

Received: March 11, 2008 Revised: May 26, 2008

Accepted: May 28, 2008

Publication Date:
29 July 2008 (online)

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Abstract

An in vitro T-cell migration assay has been established that can be used to study the effects of compounds on the development of T-cell polarisation with HuT-78 T lymphocytes. This assay indicates the ability of compounds tested to inhibit the inflammatory response by decreasing LFA-1-mediated T-cell motility. The effect of a series of naturally occurring quinone isolates on motility has been evaluated in this assay. Distinct differences have been observed between naphthoquinones, dihydrofuranonaphthoquinones and anthraquinones

References

Dr. Dr. Helen Sheridan

Trinity College Dublin

School of Pharmacy & Pharmaceutical Sciences

Panoz Institute

23 Westland Row

Dublin 2

Ireland

Fax: 353-1-608-2804

Email: hsheridn@tcd.ie

Email: nfrnkish@tcd.ie