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Synfacts 2008(9): 0963-0963
DOI: 10.1055/s-2008-1078664
DOI: 10.1055/s-2008-1078664
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Enantioselective Conjugate Allylation of Activated a,b-Enones
M. Shizuka, M. L. Snapper*
Boston College, Chestnut Hill, USA
Further Information
Publication History
Publication Date:
22 August 2008 (online)

Significance
Even though there are several highly effective protocols for the addition of allylsilanes to carbonyl compounds, the methods for asymmetric 1,4-addition are still rare. In this report by Snapper’s group a highly efficient method for the introduction of an allyl group in an asymmetric 1,4-addition manner is described. The reaction proceeds under mild conditions to provide products in high yield and moderate to high enantioselectivities.