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Synfacts 2008(9): 0998-0998  
DOI: 10.1055/s-2008-1078657
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Hydrogen-Transfer Amination of Aldehydes

Contributor(s): Yasuhiro Uozumi, Go Hamasaka
F. Alonso*, P. Riente, M. Yus*
Universidad de Alicante, Spain
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Publication History

Publication Date:
22 August 2008 (online)

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Significance

Nickel nanoparticles (NiNPs) were generated from anhydrous nickel(II) chloride by treatment with lithium powder and a catalytic amount of 4,4¢-di-tert-butylbiphenyl (DTBB, 5 mol%) in THF at room temperature. The hydrogen-transfer reductive amination of aldehydes 1 with amines 2 was carried out in the presence of NiNPs in i-PrOH to give the corresponding products 3 in 30-99% yield (20 examples).