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Synfacts 2008(9): 0950-0950  
DOI: 10.1055/s-2008-1078638
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Enantioselective Sc(III)-Catalyzed Direct Allylation of Aldimines

Contributor(s): Mark Lautens, Valentina Aureggi
X. Li, X. Liu, Y. Fu, L. Wang, L. Zhou, X. Feng*
Sichuan University, Chengdu, P. R. of China
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Publikationsdatum:
22. August 2008 (online)

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Significance

The efficient catalytic asymmetric three-component allylation of aldimines is reported. The resulting optically active homoallylic amines are versatile intermediates in the organic synthesis and are obtained in high yield with excellent enantioselectivity under mild conditions. This paper builds on previous work in the field pioneered by Mosset, Wips, and Kobayashi (e.g., see: B. Choucair, H. Léon, M.-A. Miré, C. Lebreton, P. Mosset Org. Lett. 2000, 2, 1851).