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Synfacts 2008(9): 0973-0973  
DOI: 10.1055/s-2008-1078629
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Direct Cu(II)-Catalyzed Arylation of Indoles: Switchable Regioselectivity

Contributor(s): Paul Knochel, Tobias Thaler
R. J. Phipps, N. P. Grimster, M. J. Gaunt*
University of Cambridge, UK
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Publication History

Publication Date:
22 August 2008 (online)

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Significance

A novel method for the site-selective functionalization of indoles is presented in this article. Hereby, Cu(OTf)2 was found to efficiently catalyze the transfer of different aryl groups from diaryliodine(III) reagents to variously substituted indoles. This reaction is suggested to proceed via a reactive Cu(III)-aryl intermediate.