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Synfacts 2008(9): 0975-0975  
DOI: 10.1055/s-2008-1078623
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Mild Transesterification of Methyl Esters Catalyzed by a Zinc Cluster

Contributor(s): Paul Knochel, Andrey Gavryushin
T. Iwasaki, Y. Maegawa, Y. Hayashi, T. Ohshima*, K. Mashima*
Osaka University, Japan
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Publication History

Publication Date:
22 August 2008 (online)

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Significance

A highly efficient, general catalytic method of transesterification of methyl esters is reported. The reaction occurs under relatively mild conditions. This method can be successfully applied to a variety of substrates, including enantio­pure aminoacids and oligopeptides. Most widely used protecting groups are not affected during this process. Acid-sensitive allylic alcohols like geraniol also react smoothly.