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Synfacts 2008(8): 0827-0827
DOI: 10.1055/s-2008-1078559
DOI: 10.1055/s-2008-1078559
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Enantioselective Suzuki Coupling of Unactivated Alkyl Halides
B. Saito, G. C. Fu*
Massachusetts Institute of Technology, Cambridge, USA
Further Information
Publication History
Publication Date:
23 July 2008 (online)
Significance
Nickel catalysts have been shown to be efficient promoters of the cross-coupling reactions of secondary halides. In this case, the authors have successfully expanded the nickel-catalyzed Suzuki coupling reaction to unactivated homobenzylic halides. In addition, the reactions are carried out in a highly enantioselective fashion under mild conditions. The main advantages of this methodology are broad substrate scope, clean conversion and the use of a commercial ligand that provides the products with high enantioselectivity.