PDF herunterladen
Synfacts 2008(8): 0791-0791  
DOI: 10.1055/s-2008-1078528
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Formal Synthesis of Neopeltolide

Contributor(s): Philip Kocienski, Indu Dager
V. V. Vintonyak, M. E. Maier*
Universität Tübingen, Germany
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
23. Juli 2008 (online)

   Lizenzen und Reprints
Preview

Significance

Neopeltolide, a marine macrolide isolated from the sponge related to genus Daedalopelta sollas, inhibits the proliferation of adenocarcinoma, ovarian sarcoma and murine leukemia. The Prins cyclization to form the pyran ring in I features as the key step.