Download PDF
Synfacts 2008(8): 0795-0795  
DOI: 10.1055/s-2008-1078527
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (+)-Lactacystin

Contributor(s): Philip Kocienski, Arndt W. Schmidt
C. J. Hayes*, A. E. Sherlock, M. P. Green, C. Wilson, A. J. Blake, M. D. Selby, J. C. Prodger
University of Nottingham, Pfitzer Global Research and Development, Kent and GlaxoSmithKline Medicines Research Centre, Stevenage, UK
Further Information

Publication History

Publication Date:
23 July 2008 (online)

    Permissions and Reprints

Significance

A formal synthesis of (+)-lactacystin and its biological precursor omuralide was reported by the same group earlier. Herein a scalable approach to H is reported as well as a new endgame strategy. Unprotected H is an intermediate in a previous synthesis (H. Uno, J. E. Baldwin, A. T. Russell J. Am. Chem. Soc. 1994, 116, 2139).