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Synfacts 2008(6): 0622-0622  
DOI: 10.1055/s-2008-1078396
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Aluminum(salalen)-Catalyzed Oxidation of Sulfides

Contributor(s): Mark Lautens, Valentina Aureggi
K. Matsumoto, T. Yamaguchi, T. Katsuki*
Kyushu University, Fukuoka, Japan
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Publikationsdatum:
21. Mai 2008 (online)

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Significance

The development of a highly efficient aluminum-catalyzed enantioselective oxidation of sulfides under solvent-free or highly concentrated conditions is reported. The corresponding optically active sulfoxides are obtained in good yields with high to excellent enantio­selectivities. This versatile methodology is one of the few examples of enantioselective oxidation under solvent-free conditions.