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Synfacts 2008(9): 0941-0941  
DOI: 10.1055/s-2008-1078002
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

New Ligand for Asymmetric Catalytic Hydrogenation of Alkenes

Contributor(s): Hisashi Yamamoto, Joshua P. Abell
M. Diéguez*, J. Mazuela, O. Pàmies, J. J. Verendel, P. G. Andersson*
Universitat Rovira i Virgili, Tarragona, Spain and Uppsala University, Sweden
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Publication History

Publication Date:
22 August 2008 (online)

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Significance

Several privileged P,N-ligands for
Ir-catalyzed asymmetric hydrogenation have been reported. Less electron-rich phosphite ligands have shown potential for use in asymmetric reactions using rhodium and iridium. This work uses this information to design a simple phosphite ligand which demonstrated high activity and enantioselectivity of a broad range of alkenes.