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Synfacts 2008(9): 0907-0907
DOI: 10.1055/s-2008-1077990
DOI: 10.1055/s-2008-1077990
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New York
Formal Synthesis of Fluvirucinine A1
S. Son, G. C. Fu*
Massachusetts Institute of Technology, Cambridge, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
22. August 2008 (online)

Significance
The target is an aglycone of fluvirucin A1, a macrolide isolated from the fermentation broth of some Actinomycete strains, showing potent activity against influenza A. The formal synthesis depicted focuses on two very efficient enantioselective Negishi-type cross-couplings (A + B → D and E + F → G).