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Synfacts 2008(9): 0899-0899
DOI: 10.1055/s-2008-1077989
DOI: 10.1055/s-2008-1077989
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New YorkFormal Synthesis of Fostriecin
Y. Hayashi*, H. Yamaguchi, M. Toyoshima, K. Okado, T. Toyo, M. Shoji
Tokyo University of Science, Japan
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
22. August 2008 (online)
Significance
An alkyne-cobalt complex was employed to control diastereoselective allylation of a chiral 4-substituted ynal (1,4-asymmetric induction). The closer proximity of C-5 and C-8 in the cobalt complex C is the key for achieving a high diastereoselectivity. The basic concept has been applied to a formal synthesis of fostriecin.