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Synfacts 2008(9): 0904-0904  
DOI: 10.1055/s-2008-1077987
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (±)-Minfiensine

Contributor(s): Philip Kocienski
L. Shen, M. Zhang, Y. Wu, Y. Qin*
West China School of Pharmacy and Sichuan University, Chengdu, P. R. of China
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Publication History

Publication Date:
22 August 2008 (online)

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Significance

A highly efficient synthesis of (±)-minfiensine features a three-step, one-pot cascade reaction initiated by cyclopropanation of indole A to give the tetracycle D in 50% yield.