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Synfacts 2008(9): 0901-0901  
DOI: 10.1055/s-2008-1077983
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Spirastrellolide A Methyl Ester

Contributor(s): Philip Kocienski, Arndt W. Schmidt
I. Paterson*, E. A. Anderson, S. M. Dalby, J. H. Lim, J. Genovino, P. Maltas, C. Moessner
University of Cambridge, UK
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Publikationsdatum:
22. August 2008 (online)

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Significance

Spirastrellolide A is a potent protein phosphatase inhibitor. This first total synthesis ­relays on a highly convergent strategy. The desired compound was obtained in 0.07% yield after a longest linear sequence of 38 steps.