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Synfacts 2008(8): 0894-0894  
DOI: 10.1055/s-2008-1077921
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Aminocarbonylation Inside a Flow Reactor

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada
C. Csajági*, B. Borcsek, K. Niesz, I. Kovács, Z. Székelyhidi, Z. Bajkó, L. Ürge, F. Darvas
ThalesNano Inc., Budapest, Hungary
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Publication History

Publication Date:
23 July 2008 (online)

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Significance

Haloganated arenecarboxylic acids were converted into the corresponding dicarboxylic acid monoamides by aminocarbonylation mediated by a supported Pd catalyst inside a flow reactor (X-CubeTM). Thus, a gas-liquid mixture of CO gas and a THF solution of 4-iodobenzoic acid, pyrrolidine and triethylamine was passed with a 0.5 mL/min flow rate at 100 ˚C through a cartridge (CatCartTM) where polymer-supported tetra­kis(triphenylphosphine)palladium was packed. The corresponding dicarboxylic acid monoamides were obtained in 25-81% yield (13 examples) within two minutes of the residence time.