DMW - Deutsche Medizinische Wochenschrift, Table of Contents Dtsch Med Wochenschr 2008; 133(15): 777-781DOI: 10.1055/s-2008-1075646 Prinzip & Perspektive | Review articleGrundlagenforschung, Molekularbiologie© Georg Thieme Verlag KG Stuttgart · New YorkChaperono- und Proteinopathien: molekulare Grundlagen - künftige TherapienChaperono- and proteinopathies: molecular basis - novel therapeutic optionsC. P. Maier1 1 Medizinische Universitätsklinik Freiburg, Abteilung Innere Medizin II Recommend Article Abstract Buy Article Schlüsselwörter Chaperonopathien - Proteinopathien Key words chaperonopathies - proteinopathies Full Text References Literatur 1 Ansar S, Burlison J A, Hadden M K. et al . A non-toxic Hsp90 inhibitor protects neurons from Abeta-induced toxicity. Bioorg Med Chem Lett. 2007; 17 (7) 1984-90 2 Barral J M, Broadley S A, Schaffar G, Hartl F U. Roles of molecular chaperones in protein misfolding diseases. Semin Cell Dev Biol. 2004; 15 (1) 17-29 3 Bence N F, Sampat R M, Kopito R R. Impairment of the ubiquitin-proteasome system by protein aggregation. Science. 2001; 292 (5521) 1552-5 4 Di Tommaso L, Franchi G, Park Y N. et al . Diagnostic value of HSP70, glypican 3, and glutamine synthetase in hepatocellular nodules in cirrhosis. Hepatology. 2007; 45 (3) 725-34 5 Greiner J, Ringhoffer M, Taniguchi M. et al . Characterization of several leukemia-associated antigens inducing humoral immune responses in acute and chronic myeloid leukemia. Int J Cancer. 2003; 106 (2) 224-31 6 Macario A J, Macario de Conway E. Chaperonopathies and chaperonotherapy. FEBS Lett. 2007; 581 (19) 3681-8 7 Macario A J, Macario de Conway E. Chaperonopathies by defect, excess, or mistake. Ann N Y Acad Sci. 2007; 1113 178-91 8 Macario A J, Macario de Conway E. Molecular chaperones: multiple functions, pathologies, and potential applications. Front Biosci. 2007; 12 2588-600 9 Macario A J, Macario de Conway E. Sick chaperones and ageing: a perspective. Ageing Res Rev. 2002; 1 (2) 295-311 10 Macario A J, Macario de Conway E. Sick chaperones, cellular stress, and disease. N Engl J Med. 2005; 353 (14) 1489-501 11 Macario A J, Macario de Conway E. Stress and molecular chaperones in disease. Int J Clin Lab Res. 2000; 30 (2) 49-66 12 Macario A J, Macario de Conway E. The pathology of cellular anti-stress mechanisms: a new frontier. Stress. 2004; 7 (4) 243-9 13 Otto H, Conz C, Maier P. et al . The chaperones MPP11 and Hsp70L1 form the mammalian ribosome-associated complex. Proc Natl Acad Sci U S A. 2005; 102 (29) 10 064-9 14 Pacey S, Banerji U, Judson I, Workman P. Hsp90 inhibitors in the clinic. Handb Exp Pharmacol. 2006; (172) 331-58 15 Selkoe D J. Folding proteins in fatal ways. Nature. 2003; 426 (6968) 900-4 16 Slavotinek A M, Biesecker L G. Unfolding the role of chaperones and chaperonins in human disease. Trends Genet. 2001; 17 (9) 528-35 17 Sreedhar A S, Csermely P. Heat shock proteins in the regulation of apoptosis: new strategies in tumor therapy: a comprehensive review. Pharmacol Ther. 2004; 101 (3) 227-57 18 Young J C, Agashe V R, Siegers K, Hartl F U. Pathways of chaperone-mediated protein folding in the cytosol. Nat Rev Mol Cell Biol. 2004; 5 (10) 781-91 Cand. med. Claus Philipp Maier Abteilung Innere Medizin II, Medizinische Universitätsklinik Hugstetter Str. 55 79106 Freiburg Phone: 0761/2703-404 Fax: 0761/2703-610 Email: Philipp_Maier@gmx.de