FeCl3-Catalysed Cleavage of 1,2-Butanediacetal Protected Diols

C. Christoph Tzschucke; Narathip Pradidphol; Alejandro Diéguez-Vázquez; Boonsong Kongkathip; Ngampong Kongkathip; Steven V. Ley

doi:10.1055/s-2008-1072752

LETTER

FeCl₃-Catalysed Cleavage of 1,2-Butanediacetal Protected Diols

C. Christoph Tzschucke^a, Narathip Pradidphol^a, Alejandro Diéguez-Vázquez^a, Boonsong Kongkathip^b, Ngampong Kongkathip^b, Steven V. Ley*^a
^a Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
Fax: +44(1223)336442; e-Mail: svl1000@cam.ac.uk;
^b Department of Chemistry, Kasetsart University, Bangkok, Thailand

Abstract

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Abstract

Catalytic FeCl₃ in acetic acid has been employed as a cost-effective, low-toxicity reagent for the removal of butane 1,2-diacetal protecting groups under mild conditions.

Key words

protecting groups - diols - hydrolysis - acetals - iron

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References

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