Synthesis of Chlorotonil A

Significance

The structure of the myxobacterium Sorangium cellulosum metabolite chlorotonil A was assigned in 2008 (K. Gerth, H. Steinmetz, G. Höfle, R. Jansen Angew. Chem. Int. Ed. 2008, 47, 160). The double carbonyl flanked CCl₂ motif and promising first biological data render this molecule an interesting synthetic target.